Evidence network for deaths_(OS)

2IMpassion-130 (all population), 2018 IMpassion-130 (PDL1>1%), 20182IMpassion-131 (PD-L1 > 1%), 2020 IMpassion-131 (all population), 20203KEYNOTE-355 (all population), 2020 KEYNOTE-355 (CPS>1), 2020 KEYNOTE-355 (CPS>10), 20202PAKT (all population), 2020 PAKT (PIK3CA/AKT1/PTEN-altered), 20201LOTUS, 20171BrighTNess (velaparib-P-C (arm A) vs paclitaxel alone (arm C)), 20182TORCHLIGHT, 2024 TORCHLIGHT PDL 1 positive population, 2024atezolizumab plus nab-paclitaxel vs. atezolizumab plus paclitaxel atezolizumab plus nab-paclitaxel better 0.73 [0.57; 0.94]0.73 [0.57;0.94]atezolizumab plus nab-paclitaxel vs. atezolizumab plus paclitaxel atezolizumab plus nab-paclitaxel better 0.73 [0.57; 0.94]atezolizumab plus nab-paclitaxel vs. capivasertib plus paclitaxel 1.45 [0.90; 2.33]1.45 [0.90;2.33]atezolizumab plus nab-paclitaxel vs. capivasertib plus paclitaxel 1.45 [0.90; 2.33]atezolizumab plus nab-paclitaxel vs. ipatasertib plus paclitaxel 1.02 [0.62; 1.67]1.02 [0.62;1.67]atezolizumab plus nab-paclitaxel vs. ipatasertib plus paclitaxel 1.02 [0.62; 1.67]atezolizumab plus nab-paclitaxel vs. pembrolizumab plus SoC 0.96 [0.80; 1.15]0.96 [0.80;1.15]atezolizumab plus nab-paclitaxel vs. pembrolizumab plus SoC 0.96 [0.80; 1.15]atezolizumab plus nab-paclitaxel vs. Standard of Care (SoC) atezolizumab plus nab-paclitaxel better 0.81 [0.70; 0.94]0.81 [0.70;0.94]atezolizumab plus nab-paclitaxel vs. Standard of Care (SoC) atezolizumab plus nab-paclitaxel better 0.81 [0.70; 0.94]atezolizumab plus nab-paclitaxel vs. veliparib plus paclitaxel plus carboplatin 0.99 [0.57; 1.72]0.99 [0.57;1.72]atezolizumab plus nab-paclitaxel vs. veliparib plus paclitaxel plus carboplatin 0.99 [0.57; 1.72]atezolizumab plus paclitaxel vs. atezolizumab plus nab-paclitaxel atezolizumab plus nab-paclitaxel better 1.37 [1.07; 1.77]1.37 [1.07;1.77]atezolizumab plus paclitaxel vs. atezolizumab plus nab-paclitaxel atezolizumab plus nab-paclitaxel better 1.37 [1.07; 1.77]atezolizumab plus paclitaxel vs. capivasertib plus paclitaxel capivasertib plus paclitaxel better 1.99 [1.21; 3.26]1.99 [1.21;3.26]atezolizumab plus paclitaxel vs. capivasertib plus paclitaxel capivasertib plus paclitaxel better 1.99 [1.21; 3.26]atezolizumab plus paclitaxel vs. ipatasertib plus paclitaxel 1.40 [0.84; 2.33]1.40 [0.84;2.33]atezolizumab plus paclitaxel vs. ipatasertib plus paclitaxel 1.40 [0.84; 2.33]atezolizumab plus paclitaxel vs. pembrolizumab plus SoC pembrolizumab plus SoC better 1.31 [1.04; 1.66]1.31 [1.04;1.66]atezolizumab plus paclitaxel vs. pembrolizumab plus SoC pembrolizumab plus SoC better 1.31 [1.04; 1.66]atezolizumab plus paclitaxel vs. Standard of Care (SoC) 1.12 [0.91; 1.37]1.12 [0.91;1.37]atezolizumab plus paclitaxel vs. Standard of Care (SoC) 1.12 [0.91; 1.37]atezolizumab plus paclitaxel vs. veliparib plus paclitaxel plus carboplatin 1.36 [0.77; 2.40]1.36 [0.77;2.40]atezolizumab plus paclitaxel vs. veliparib plus paclitaxel plus carboplatin 1.36 [0.77; 2.40]capivasertib plus paclitaxel vs. atezolizumab plus nab-paclitaxel 0.69 [0.43; 1.11]0.69 [0.43;1.11]capivasertib plus paclitaxel vs. atezolizumab plus nab-paclitaxel 0.69 [0.43; 1.11]capivasertib plus paclitaxel vs. atezolizumab plus paclitaxel capivasertib plus paclitaxel better 0.50 [0.31; 0.83]0.50 [0.31;0.83]capivasertib plus paclitaxel vs. atezolizumab plus paclitaxel capivasertib plus paclitaxel better 0.50 [0.31; 0.83]capivasertib plus paclitaxel vs. ipatasertib plus paclitaxel 0.70 [0.37; 1.35]0.70 [0.37;1.35]capivasertib plus paclitaxel vs. ipatasertib plus paclitaxel 0.70 [0.37; 1.35]capivasertib plus paclitaxel vs. pembrolizumab plus SoC 0.66 [0.42; 1.05]0.66 [0.42;1.05]capivasertib plus paclitaxel vs. pembrolizumab plus SoC 0.66 [0.42; 1.05]capivasertib plus paclitaxel vs. Standard of Care (SoC) capivasertib plus paclitaxel better 0.56 [0.36; 0.88]0.56 [0.36;0.88]capivasertib plus paclitaxel vs. Standard of Care (SoC) capivasertib plus paclitaxel better 0.56 [0.36; 0.88]capivasertib plus paclitaxel vs. veliparib plus paclitaxel plus carboplatin 0.69 [0.34; 1.37]0.69 [0.34;1.37]capivasertib plus paclitaxel vs. veliparib plus paclitaxel plus carboplatin 0.69 [0.34; 1.37]ipatasertib plus paclitaxel vs. atezolizumab plus nab-paclitaxel 0.98 [0.60; 1.61]0.98 [0.60;1.61]ipatasertib plus paclitaxel vs. atezolizumab plus nab-paclitaxel 0.98 [0.60; 1.61]ipatasertib plus paclitaxel vs. atezolizumab plus paclitaxel 0.72 [0.43; 1.20]0.72 [0.43;1.20]ipatasertib plus paclitaxel vs. atezolizumab plus paclitaxel 0.72 [0.43; 1.20]ipatasertib plus paclitaxel vs. capivasertib plus paclitaxel 1.42 [0.74; 2.73]1.42 [0.74;2.73]ipatasertib plus paclitaxel vs. capivasertib plus paclitaxel 1.42 [0.74; 2.73]ipatasertib plus paclitaxel vs. pembrolizumab plus SoC 0.94 [0.58; 1.52]0.94 [0.58;1.52]ipatasertib plus paclitaxel vs. pembrolizumab plus SoC 0.94 [0.58; 1.52]ipatasertib plus paclitaxel vs. Standard of Care (SoC) 0.80 [0.50; 1.28]0.80 [0.50;1.28]ipatasertib plus paclitaxel vs. Standard of Care (SoC) 0.80 [0.50; 1.28]ipatasertib plus paclitaxel vs. veliparib plus paclitaxel plus carboplatin 0.98 [0.48; 1.98]0.98 [0.48;1.98]ipatasertib plus paclitaxel vs. veliparib plus paclitaxel plus carboplatin 0.98 [0.48; 1.98]pembrolizumab plus SoC vs. atezolizumab plus nab-paclitaxel 1.04 [0.87; 1.26]1.04 [0.87;1.26]pembrolizumab plus SoC vs. atezolizumab plus nab-paclitaxel 1.04 [0.87; 1.26]pembrolizumab plus SoC vs. atezolizumab plus paclitaxel pembrolizumab plus SoC better 0.76 [0.60; 0.96]0.76 [0.60;0.96]pembrolizumab plus SoC vs. atezolizumab plus paclitaxel pembrolizumab plus SoC better 0.76 [0.60; 0.96]pembrolizumab plus SoC vs. capivasertib plus paclitaxel 1.51 [0.95; 2.41]1.51 [0.95;2.41]pembrolizumab plus SoC vs. capivasertib plus paclitaxel 1.51 [0.95; 2.41]pembrolizumab plus SoC vs. ipatasertib plus paclitaxel 1.06 [0.66; 1.72]1.06 [0.66;1.72]pembrolizumab plus SoC vs. ipatasertib plus paclitaxel 1.06 [0.66; 1.72]pembrolizumab plus SoC vs. Standard of Care (SoC) pembrolizumab plus SoC better 0.85 [0.76; 0.95]0.85 [0.76;0.95]pembrolizumab plus SoC vs. Standard of Care (SoC) pembrolizumab plus SoC better 0.85 [0.76; 0.95]pembrolizumab plus SoC vs. veliparib plus paclitaxel plus carboplatin 1.04 [0.60; 1.78]1.04 [0.60;1.78]pembrolizumab plus SoC vs. veliparib plus paclitaxel plus carboplatin 1.04 [0.60; 1.78]Standard of Care (SoC) vs. atezolizumab plus nab-paclitaxel atezolizumab plus nab-paclitaxel better 1.23 [1.06; 1.42]1.23 [1.06;1.42]Standard of Care (SoC) vs. atezolizumab plus nab-paclitaxel atezolizumab plus nab-paclitaxel better 1.23 [1.06; 1.42]Standard of Care (SoC) vs. atezolizumab plus paclitaxel 0.90 [0.73; 1.10]0.90 [0.73;1.10]Standard of Care (SoC) vs. atezolizumab plus paclitaxel 0.90 [0.73; 1.10]Standard of Care (SoC) vs. capivasertib plus paclitaxel capivasertib plus paclitaxel better 1.78 [1.13; 2.79]1.78 [1.13;2.79]Standard of Care (SoC) vs. capivasertib plus paclitaxel capivasertib plus paclitaxel better 1.78 [1.13; 2.79]Standard of Care (SoC) vs. ipatasertib plus paclitaxel 1.25 [0.78; 2.00]1.25 [0.78;2.00]Standard of Care (SoC) vs. ipatasertib plus paclitaxel 1.25 [0.78; 2.00]Standard of Care (SoC) vs. pembrolizumab plus SoC pembrolizumab plus SoC better 1.18 [1.05; 1.31]1.18 [1.05;1.31]Standard of Care (SoC) vs. pembrolizumab plus SoC pembrolizumab plus SoC better 1.18 [1.05; 1.31]Standard of Care (SoC) vs. veliparib plus paclitaxel plus carboplatin 1.22 [0.72; 2.07]1.22 [0.72;2.07]Standard of Care (SoC) vs. veliparib plus paclitaxel plus carboplatin 1.22 [0.72; 2.07]veliparib plus paclitaxel plus carboplatin vs. atezolizumab plus nab-paclitaxel 1.01 [0.58; 1.74]1.01 [0.58;1.74]veliparib plus paclitaxel plus carboplatin vs. atezolizumab plus nab-paclitaxel 1.01 [0.58; 1.74]veliparib plus paclitaxel plus carboplatin vs. atezolizumab plus paclitaxel 0.73 [0.42; 1.29]0.73 [0.42;1.29]veliparib plus paclitaxel plus carboplatin vs. atezolizumab plus paclitaxel 0.73 [0.42; 1.29]veliparib plus paclitaxel plus carboplatin vs. capivasertib plus paclitaxel 1.46 [0.73; 2.92]1.46 [0.73;2.92]veliparib plus paclitaxel plus carboplatin vs. capivasertib plus paclitaxel 1.46 [0.73; 2.92]veliparib plus paclitaxel plus carboplatin vs. ipatasertib plus paclitaxel 1.02 [0.51; 2.08]1.02 [0.51;2.08]veliparib plus paclitaxel plus carboplatin vs. ipatasertib plus paclitaxel 1.02 [0.51; 2.08]veliparib plus paclitaxel plus carboplatin vs. pembrolizumab plus SoC 0.96 [0.56; 1.65]0.96 [0.56;1.65]veliparib plus paclitaxel plus carboplatin vs. pembrolizumab plus SoC 0.96 [0.56; 1.65]veliparib plus paclitaxel plus carboplatin vs. Standard of Care (SoC) 0.82 [0.48; 1.39]0.82 [0.48;1.39]veliparib plus paclitaxel plus carboplatin vs. Standard of Care (SoC) 0.82 [0.48; 1.39]nab-paclitaxelpaclitaxelStandard of Care (SoC)nab-paclitaxel plus placeboatezolizumab plus nab-paclitaxelatezolizumab plus paclitaxelpembrolizumab plus SoCcapivasertib plus paclitaxelipatasertib plus paclitaxelveliparib plus paclitaxel plus carboplatinnab-paclitaxel plus toripalimabcamrelizumab alonedirect evidencenetwork meta-analysis
T vs. C nab-paclitaxelpaclitaxelStandard of Care (SoC)nab-paclitaxel plus placeboatezolizumab plus nab-paclitaxelatezolizumab plus paclitaxelpembrolizumab plus SoCcapivasertib plus paclitaxelipatasertib plus paclitaxelveliparib plus paclitaxel plus carboplatinnab-paclitaxel plus toripalimabcamrelizumab alone
nab-paclitaxel---NANANANANANANANANANANA
paclitaxelNA---NANANANANANANANANANA
Standard of Care (SoC)NANA---NA1.23
1.06; 1.42		0.90
0.73; 1.10		1.18
1.05; 1.31		1.78
1.13; 2.79		1.25
0.78; 2.00		1.22
0.72; 2.07		NANA
nab-paclitaxel plus placeboNANANA---NANANANANANANANA
atezolizumab plus nab-paclitaxelNANA0.81
0.70; 0.94		NA---0.73
0.57; 0.94		0.96
0.80; 1.15		1.45
0.90; 2.33		1.02
0.62; 1.67		0.99
0.57; 1.72		NANA
atezolizumab plus paclitaxelNANA1.12
0.91; 1.37		NA1.37
1.07; 1.77		---1.31
1.04; 1.66		1.99
1.21; 3.26		1.40
0.84; 2.33		1.36
0.77; 2.40		NANA
pembrolizumab plus SoCNANA0.85
0.76; 0.95		NA1.04
0.87; 1.26		0.76
0.60; 0.96		---1.51
0.95; 2.41		1.06
0.66; 1.72		1.04
0.60; 1.78		NANA
capivasertib plus paclitaxelNANA0.56
0.36; 0.88		NA0.69
0.43; 1.11		0.50
0.31; 0.83		0.66
0.42; 1.05		---0.70
0.37; 1.35		0.69
0.34; 1.37		NANA
ipatasertib plus paclitaxelNANA0.80
0.50; 1.28		NA0.98
0.60; 1.61		0.72
0.43; 1.20		0.94
0.58; 1.52		1.42
0.74; 2.73		---0.98
0.48; 1.98		NANA
veliparib plus paclitaxel plus carboplatinNANA0.82
0.48; 1.39		NA1.01
0.58; 1.74		0.73
0.42; 1.29		0.96
0.56; 1.65		1.46
0.73; 2.92		1.02
0.51; 2.08		---NANA
nab-paclitaxel plus toripalimabNANANANANANANANANANA---NA
camrelizumab aloneNANANANANANANANANANANA---

pathologies: 269,60,143 - treatments: 661 result logic

 

- About us - Contact us - Method - RSS Made with in Lyon - Credits - Privacy policy - Licence Creative Commons