Network meta-analysis for deaths_(OS)

Network meta-analysis estimations pool direct and indirect evidences. These results should be considered as exploratory given the absence of assessment of transitivity assumption plausibility. Calculations by netmeta package.

Evidence network for deaths_(OS)

1MDX010 Ipi vs gp100, 20101Ascierto (ipi 10 vs 3 mg/kg), 20171KEYNOTE-002 (2 mg/kg), 20151CA184-024, 20111CheckMate 037, 20151KEYNOTE-006 (2 week), 20151KEYNOTE-006 (3 week), 20151KEYNOTE-002 (10 mg/kg), 20151MDX010 Ipi plus gp100 vs gp100, 20101MDX010 Ipi plus gp100 vs Ipi (EXPLORATORY), 2010gp100 vs. ipilimumab alone ipilimumab alone better 1.52 [1.24; 1.86]1.52 [1.24;1.86]gp100 vs. ipilimumab alone ipilimumab alone better 1.52 [1.24; 1.86]gp100 vs. ipilimumab plus gp100 ipilimumab plus gp100 better 1.47 [1.22; 1.76]1.47 [1.22;1.76]gp100 vs. ipilimumab plus gp100 ipilimumab plus gp100 better 1.47 [1.22; 1.76]gp100 vs. ipilimumab plus SoC ipilimumab plus SoC better 2.27 [1.41; 3.63]2.27 [1.41;3.63]gp100 vs. ipilimumab plus SoC ipilimumab plus SoC better 2.27 [1.41; 3.63]gp100 vs. nivolumab alone nivolumab alone better 1.72 [1.04; 2.84]1.72 [1.04;2.84]gp100 vs. nivolumab alone nivolumab alone better 1.72 [1.04; 2.84]gp100 vs. pembrolizumab (10mg/kg) pembrolizumab (10mg/kg) better 2.20 [1.57; 3.10]2.20 [1.57;3.10]gp100 vs. pembrolizumab (10mg/kg) pembrolizumab (10mg/kg) better 2.20 [1.57; 3.10]gp100 vs. pembrolizumab (10mg/kg) 2 weeks pembrolizumab (10mg/kg) 2 weeks better 2.41 [1.70; 3.42]2.41 [1.70;3.42]gp100 vs. pembrolizumab (10mg/kg) 2 weeks pembrolizumab (10mg/kg) 2 weeks better 2.41 [1.70; 3.42]gp100 vs. pembrolizumab (2mg/kg) pembrolizumab (2mg/kg) better 1.90 [1.16; 3.11]1.90 [1.16;3.11]gp100 vs. pembrolizumab (2mg/kg) pembrolizumab (2mg/kg) better 1.90 [1.16; 3.11]gp100 vs. Standard of Care (SoC) Standard of Care (SoC) better 1.63 [1.06; 2.51]1.63 [1.06;2.51]gp100 vs. Standard of Care (SoC) Standard of Care (SoC) better 1.63 [1.06; 2.51]ipilimumab alone vs. gp100 ipilimumab alone better 0.66 [0.54; 0.81]0.66 [0.54;0.81]ipilimumab alone vs. gp100 ipilimumab alone better 0.66 [0.54; 0.81]ipilimumab alone vs. ipilimumab plus gp100 0.96 [0.80; 1.16]0.96 [0.80;1.16]ipilimumab alone vs. ipilimumab plus gp100 0.96 [0.80; 1.16]ipilimumab alone vs. ipilimumab plus SoC 1.49 [0.97; 2.28]1.49 [0.97;2.28]ipilimumab alone vs. ipilimumab plus SoC 1.49 [0.97; 2.28]ipilimumab alone vs. nivolumab alone 1.13 [0.71; 1.79]1.13 [0.71;1.79]ipilimumab alone vs. nivolumab alone 1.13 [0.71; 1.79]ipilimumab alone vs. pembrolizumab (10mg/kg) pembrolizumab (10mg/kg) better 1.45 [1.10; 1.91]1.45 [1.10;1.91]ipilimumab alone vs. pembrolizumab (10mg/kg) pembrolizumab (10mg/kg) better 1.45 [1.10; 1.91]ipilimumab alone vs. pembrolizumab (10mg/kg) 2 weeks pembrolizumab (10mg/kg) 2 weeks better 1.59 [1.19; 2.11]1.59 [1.19;2.11]ipilimumab alone vs. pembrolizumab (10mg/kg) 2 weeks pembrolizumab (10mg/kg) 2 weeks better 1.59 [1.19; 2.11]ipilimumab alone vs. pembrolizumab (2mg/kg) 1.25 [0.79; 1.96]1.25 [0.79;1.96]ipilimumab alone vs. pembrolizumab (2mg/kg) 1.25 [0.79; 1.96]ipilimumab alone vs. Standard of Care (SoC) 1.07 [0.73; 1.57]1.07 [0.73;1.57]ipilimumab alone vs. Standard of Care (SoC) 1.07 [0.73; 1.57]ipilimumab plus gp100 vs. gp100 ipilimumab plus gp100 better 0.68 [0.57; 0.82]0.68 [0.57;0.82]ipilimumab plus gp100 vs. gp100 ipilimumab plus gp100 better 0.68 [0.57; 0.82]ipilimumab plus gp100 vs. ipilimumab alone 1.04 [0.86; 1.25]1.04 [0.86;1.25]ipilimumab plus gp100 vs. ipilimumab alone 1.04 [0.86; 1.25]ipilimumab plus gp100 vs. ipilimumab plus SoC 1.54 [0.97; 2.46]1.54 [0.97;2.46]ipilimumab plus gp100 vs. ipilimumab plus SoC 1.54 [0.97; 2.46]ipilimumab plus gp100 vs. nivolumab alone 1.17 [0.71; 1.93]1.17 [0.71;1.93]ipilimumab plus gp100 vs. nivolumab alone 1.17 [0.71; 1.93]ipilimumab plus gp100 vs. pembrolizumab (10mg/kg) pembrolizumab (10mg/kg) better 1.50 [1.08; 2.10]1.50 [1.08;2.10]ipilimumab plus gp100 vs. pembrolizumab (10mg/kg) pembrolizumab (10mg/kg) better 1.50 [1.08; 2.10]ipilimumab plus gp100 vs. pembrolizumab (10mg/kg) 2 weeks pembrolizumab (10mg/kg) 2 weeks better 1.65 [1.17; 2.31]1.65 [1.17;2.31]ipilimumab plus gp100 vs. pembrolizumab (10mg/kg) 2 weeks pembrolizumab (10mg/kg) 2 weeks better 1.65 [1.17; 2.31]ipilimumab plus gp100 vs. pembrolizumab (2mg/kg) 1.29 [0.79; 2.11]1.29 [0.79;2.11]ipilimumab plus gp100 vs. pembrolizumab (2mg/kg) 1.29 [0.79; 2.11]ipilimumab plus gp100 vs. Standard of Care (SoC) 1.11 [0.73; 1.70]1.11 [0.73;1.70]ipilimumab plus gp100 vs. Standard of Care (SoC) 1.11 [0.73; 1.70]ipilimumab plus SoC vs. gp100 ipilimumab plus SoC better 0.44 [0.28; 0.71]0.44 [0.28;0.71]ipilimumab plus SoC vs. gp100 ipilimumab plus SoC better 0.44 [0.28; 0.71]ipilimumab plus SoC vs. ipilimumab alone 0.67 [0.44; 1.03]0.67 [0.44;1.03]ipilimumab plus SoC vs. ipilimumab alone 0.67 [0.44; 1.03]ipilimumab plus SoC vs. ipilimumab plus gp100 0.65 [0.41; 1.03]0.65 [0.41;1.03]ipilimumab plus SoC vs. ipilimumab plus gp100 0.65 [0.41; 1.03]ipilimumab plus SoC vs. nivolumab alone 0.76 [0.55; 1.05]0.76 [0.55;1.05]ipilimumab plus SoC vs. nivolumab alone 0.76 [0.55; 1.05]ipilimumab plus SoC vs. pembrolizumab (10mg/kg) 0.97 [0.70; 1.35]0.97 [0.70;1.35]ipilimumab plus SoC vs. pembrolizumab (10mg/kg) 0.97 [0.70; 1.35]ipilimumab plus SoC vs. pembrolizumab (10mg/kg) 2 weeks 1.07 [0.64; 1.78]1.07 [0.64;1.78]ipilimumab plus SoC vs. pembrolizumab (10mg/kg) 2 weeks 1.07 [0.64; 1.78]ipilimumab plus SoC vs. pembrolizumab (2mg/kg) 0.84 [0.61; 1.15]0.84 [0.61;1.15]ipilimumab plus SoC vs. pembrolizumab (2mg/kg) 0.84 [0.61; 1.15]ipilimumab plus SoC vs. Standard of Care (SoC) ipilimumab plus SoC better 0.72 [0.59; 0.87]0.72 [0.59;0.87]ipilimumab plus SoC vs. Standard of Care (SoC) ipilimumab plus SoC better 0.72 [0.59; 0.87]nivolumab alone vs. gp100 nivolumab alone better 0.58 [0.35; 0.96]0.58 [0.35;0.96]nivolumab alone vs. gp100 nivolumab alone better 0.58 [0.35; 0.96]nivolumab alone vs. ipilimumab alone 0.89 [0.56; 1.41]0.89 [0.56;1.41]nivolumab alone vs. ipilimumab alone 0.89 [0.56; 1.41]nivolumab alone vs. ipilimumab plus gp100 0.85 [0.52; 1.41]0.85 [0.52;1.41]nivolumab alone vs. ipilimumab plus gp100 0.85 [0.52; 1.41]nivolumab alone vs. ipilimumab plus SoC 1.32 [0.95; 1.83]1.32 [0.95;1.83]nivolumab alone vs. ipilimumab plus SoC 1.32 [0.95; 1.83]nivolumab alone vs. pembrolizumab (10mg/kg) 1.28 [0.89; 1.86]1.28 [0.89;1.86]nivolumab alone vs. pembrolizumab (10mg/kg) 1.28 [0.89; 1.86]nivolumab alone vs. pembrolizumab (10mg/kg) 2 weeks 1.41 [0.82; 2.42]1.41 [0.82;2.42]nivolumab alone vs. pembrolizumab (10mg/kg) 2 weeks 1.41 [0.82; 2.42]nivolumab alone vs. pembrolizumab (2mg/kg) 1.10 [0.77; 1.59]1.10 [0.77;1.59]nivolumab alone vs. pembrolizumab (2mg/kg) 1.10 [0.77; 1.59]nivolumab alone vs. Standard of Care (SoC) 0.95 [0.73; 1.24]0.95 [0.73;1.24]nivolumab alone vs. Standard of Care (SoC) 0.95 [0.73; 1.24]pembrolizumab (10mg/kg) vs. gp100 pembrolizumab (10mg/kg) better 0.45 [0.32; 0.64]0.45 [0.32;0.64]pembrolizumab (10mg/kg) vs. gp100 pembrolizumab (10mg/kg) better 0.45 [0.32; 0.64]pembrolizumab (10mg/kg) vs. ipilimumab alone pembrolizumab (10mg/kg) better 0.69 [0.52; 0.91]0.69 [0.52;0.91]pembrolizumab (10mg/kg) vs. ipilimumab alone pembrolizumab (10mg/kg) better 0.69 [0.52; 0.91]pembrolizumab (10mg/kg) vs. ipilimumab plus gp100 pembrolizumab (10mg/kg) better 0.67 [0.48; 0.93]0.67 [0.48;0.93]pembrolizumab (10mg/kg) vs. ipilimumab plus gp100 pembrolizumab (10mg/kg) better 0.67 [0.48; 0.93]pembrolizumab (10mg/kg) vs. ipilimumab plus SoC 1.03 [0.74; 1.42]1.03 [0.74;1.42]pembrolizumab (10mg/kg) vs. ipilimumab plus SoC 1.03 [0.74; 1.42]pembrolizumab (10mg/kg) vs. nivolumab alone 0.78 [0.54; 1.13]0.78 [0.54;1.13]pembrolizumab (10mg/kg) vs. nivolumab alone 0.78 [0.54; 1.13]pembrolizumab (10mg/kg) vs. pembrolizumab (10mg/kg) 2 weeks 1.10 [0.74; 1.63]1.10 [0.74;1.63]pembrolizumab (10mg/kg) vs. pembrolizumab (10mg/kg) 2 weeks 1.10 [0.74; 1.63]pembrolizumab (10mg/kg) vs. pembrolizumab (2mg/kg) 0.86 [0.60; 1.23]0.86 [0.60;1.23]pembrolizumab (10mg/kg) vs. pembrolizumab (2mg/kg) 0.86 [0.60; 1.23]pembrolizumab (10mg/kg) vs. Standard of Care (SoC) pembrolizumab (10mg/kg) better 0.74 [0.57; 0.96]0.74 [0.57;0.96]pembrolizumab (10mg/kg) vs. Standard of Care (SoC) pembrolizumab (10mg/kg) better 0.74 [0.57; 0.96]pembrolizumab (10mg/kg) 2 weeks vs. gp100 pembrolizumab (10mg/kg) 2 weeks better 0.41 [0.29; 0.59]0.41 [0.29;0.59]pembrolizumab (10mg/kg) 2 weeks vs. gp100 pembrolizumab (10mg/kg) 2 weeks better 0.41 [0.29; 0.59]pembrolizumab (10mg/kg) 2 weeks vs. ipilimumab alone pembrolizumab (10mg/kg) 2 weeks better 0.63 [0.47; 0.84]0.63 [0.47;0.84]pembrolizumab (10mg/kg) 2 weeks vs. ipilimumab alone pembrolizumab (10mg/kg) 2 weeks better 0.63 [0.47; 0.84]pembrolizumab (10mg/kg) 2 weeks vs. ipilimumab plus gp100 pembrolizumab (10mg/kg) 2 weeks better 0.61 [0.43; 0.85]0.61 [0.43;0.85]pembrolizumab (10mg/kg) 2 weeks vs. ipilimumab plus gp100 pembrolizumab (10mg/kg) 2 weeks better 0.61 [0.43; 0.85]pembrolizumab (10mg/kg) 2 weeks vs. ipilimumab plus SoC 0.94 [0.56; 1.57]0.94 [0.56;1.57]pembrolizumab (10mg/kg) 2 weeks vs. ipilimumab plus SoC 0.94 [0.56; 1.57]pembrolizumab (10mg/kg) 2 weeks vs. nivolumab alone 0.71 [0.41; 1.22]0.71 [0.41;1.22]pembrolizumab (10mg/kg) 2 weeks vs. nivolumab alone 0.71 [0.41; 1.22]pembrolizumab (10mg/kg) 2 weeks vs. pembrolizumab (10mg/kg) 0.91 [0.62; 1.36]0.91 [0.62;1.36]pembrolizumab (10mg/kg) 2 weeks vs. pembrolizumab (10mg/kg) 0.91 [0.62; 1.36]pembrolizumab (10mg/kg) 2 weeks vs. pembrolizumab (2mg/kg) 0.79 [0.46; 1.34]0.79 [0.46;1.34]pembrolizumab (10mg/kg) 2 weeks vs. pembrolizumab (2mg/kg) 0.79 [0.46; 1.34]pembrolizumab (10mg/kg) 2 weeks vs. Standard of Care (SoC) 0.68 [0.42; 1.08]0.68 [0.42;1.08]pembrolizumab (10mg/kg) 2 weeks vs. Standard of Care (SoC) 0.68 [0.42; 1.08]pembrolizumab (2mg/kg) vs. gp100 pembrolizumab (2mg/kg) better 0.53 [0.32; 0.87]0.53 [0.32;0.87]pembrolizumab (2mg/kg) vs. gp100 pembrolizumab (2mg/kg) better 0.53 [0.32; 0.87]pembrolizumab (2mg/kg) vs. ipilimumab alone 0.80 [0.51; 1.26]0.80 [0.51;1.26]pembrolizumab (2mg/kg) vs. ipilimumab alone 0.80 [0.51; 1.26]pembrolizumab (2mg/kg) vs. ipilimumab plus gp100 0.77 [0.47; 1.26]0.77 [0.47;1.26]pembrolizumab (2mg/kg) vs. ipilimumab plus gp100 0.77 [0.47; 1.26]pembrolizumab (2mg/kg) vs. ipilimumab plus SoC 1.19 [0.87; 1.64]1.19 [0.87;1.64]pembrolizumab (2mg/kg) vs. ipilimumab plus SoC 1.19 [0.87; 1.64]pembrolizumab (2mg/kg) vs. nivolumab alone 0.91 [0.63; 1.30]0.91 [0.63;1.30]pembrolizumab (2mg/kg) vs. nivolumab alone 0.91 [0.63; 1.30]pembrolizumab (2mg/kg) vs. pembrolizumab (10mg/kg) 1.16 [0.81; 1.67]1.16 [0.81;1.67]pembrolizumab (2mg/kg) vs. pembrolizumab (10mg/kg) 1.16 [0.81; 1.67]pembrolizumab (2mg/kg) vs. pembrolizumab (10mg/kg) 2 weeks 1.27 [0.75; 2.17]1.27 [0.75;2.17]pembrolizumab (2mg/kg) vs. pembrolizumab (10mg/kg) 2 weeks 1.27 [0.75; 2.17]pembrolizumab (2mg/kg) vs. Standard of Care (SoC) 0.86 [0.67; 1.10]0.86 [0.67;1.10]pembrolizumab (2mg/kg) vs. Standard of Care (SoC) 0.86 [0.67; 1.10]Standard of Care (SoC) vs. gp100 Standard of Care (SoC) better 0.61 [0.40; 0.94]0.61 [0.40;0.94]Standard of Care (SoC) vs. gp100 Standard of Care (SoC) better 0.61 [0.40; 0.94]Standard of Care (SoC) vs. ipilimumab alone 0.93 [0.64; 1.36]0.93 [0.64;1.36]Standard of Care (SoC) vs. ipilimumab alone 0.93 [0.64; 1.36]Standard of Care (SoC) vs. ipilimumab plus gp100 0.90 [0.59; 1.37]0.90 [0.59;1.37]Standard of Care (SoC) vs. ipilimumab plus gp100 0.90 [0.59; 1.37]Standard of Care (SoC) vs. ipilimumab plus SoC ipilimumab plus SoC better 1.39 [1.14; 1.69]1.39 [1.14;1.69]Standard of Care (SoC) vs. ipilimumab plus SoC ipilimumab plus SoC better 1.39 [1.14; 1.69]Standard of Care (SoC) vs. nivolumab alone 1.05 [0.81; 1.37]1.05 [0.81;1.37]Standard of Care (SoC) vs. nivolumab alone 1.05 [0.81; 1.37]Standard of Care (SoC) vs. pembrolizumab (10mg/kg) pembrolizumab (10mg/kg) better 1.35 [1.04; 1.75]1.35 [1.04;1.75]Standard of Care (SoC) vs. pembrolizumab (10mg/kg) pembrolizumab (10mg/kg) better 1.35 [1.04; 1.75]Standard of Care (SoC) vs. pembrolizumab (10mg/kg) 2 weeks 1.48 [0.92; 2.38]1.48 [0.92;2.38]Standard of Care (SoC) vs. pembrolizumab (10mg/kg) 2 weeks 1.48 [0.92; 2.38]Standard of Care (SoC) vs. pembrolizumab (2mg/kg) 1.16 [0.91; 1.49]1.16 [0.91;1.49]Standard of Care (SoC) vs. pembrolizumab (2mg/kg) 1.16 [0.91; 1.49]Standard of Care (SoC)placebo plus SoCipilimumab alonegp100pembrolizumab (2mg/kg)ipilimumab plus SoCnivolumab aloneIpilimumab (10 mg/kg)pembrolizumab (10mg/kg) 2 weekspembrolizumab (10mg/kg)ipilimumab plus gp100direct evidencenetwork meta-analysis
T vs. C Standard of Care (SoC)placebo plus SoCipilimumab alonegp100pembrolizumab (2mg/kg)ipilimumab plus SoCnivolumab aloneIpilimumab (10 mg/kg)pembrolizumab (10mg/kg) 2 weekspembrolizumab (10mg/kg)ipilimumab plus gp100
Standard of Care (SoC)---NA0.93
0.64; 1.36		0.61
0.40; 0.94		1.16
0.91; 1.49		1.39
1.14; 1.69		1.05
0.81; 1.37		NA1.48
0.92; 2.38		1.35
1.04; 1.75		0.90
0.59; 1.37
placebo plus SoCNA---NANANANANANANANANA
ipilimumab alone1.07
0.73; 1.57		NA---0.66
0.54; 0.81		1.25
0.79; 1.96		1.49
0.97; 2.28		1.13
0.71; 1.79		NA1.59
1.19; 2.11		1.45
1.10; 1.91		0.96
0.80; 1.16
gp1001.63
1.06; 2.51		NA1.52
1.24; 1.86		---1.90
1.16; 3.11		2.27
1.41; 3.63		1.72
1.04; 2.84		NA2.41
1.70; 3.42		2.20
1.57; 3.10		1.47
1.22; 1.76
pembrolizumab (2mg/kg)0.86
0.67; 1.10		NA0.80
0.51; 1.26		0.53
0.32; 0.87		---1.19
0.87; 1.64		0.91
0.63; 1.30		NA1.27
0.75; 2.17		1.16
0.81; 1.67		0.77
0.47; 1.26
ipilimumab plus SoC0.72
0.59; 0.87		NA0.67
0.44; 1.03		0.44
0.28; 0.71		0.84
0.61; 1.15		---0.76
0.55; 1.05		NA1.07
0.64; 1.78		0.97
0.70; 1.35		0.65
0.41; 1.03
nivolumab alone0.95
0.73; 1.24		NA0.89
0.56; 1.41		0.58
0.35; 0.96		1.10
0.77; 1.59		1.32
0.95; 1.83		---NA1.41
0.82; 2.42		1.28
0.89; 1.86		0.85
0.52; 1.41
Ipilimumab (10 mg/kg)NANANANANANANA---NANANA
pembrolizumab (10mg/kg) 2 weeks0.68
0.42; 1.08		NA0.63
0.47; 0.84		0.41
0.29; 0.59		0.79
0.46; 1.34		0.94
0.56; 1.57		0.71
0.41; 1.22		NA---0.91
0.62; 1.36		0.61
0.43; 0.85
pembrolizumab (10mg/kg)0.74
0.57; 0.96		NA0.69
0.52; 0.91		0.45
0.32; 0.64		0.86
0.60; 1.23		1.03
0.74; 1.42		0.78
0.54; 1.13		NA1.10
0.74; 1.63		---0.67
0.48; 0.93
ipilimumab plus gp1001.11
0.73; 1.70		NA1.04
0.86; 1.25		0.68
0.57; 0.82		1.29
0.79; 2.11		1.54
0.97; 2.46		1.17
0.71; 1.93		NA1.65
1.17; 2.31		1.50
1.08; 2.10		---

pathologies: 69 - treatments: 549 result logic

 

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