Evidence network for deaths_(OS)

1MDX010 Ipi vs gp100, 20101Ascierto (ipi 10 vs 3 mg/kg), 20171KEYNOTE-002 (2 mg/kg), 20151CA184-024, 20111CheckMate 037, 20151KEYNOTE-006 (2 week), 20151KEYNOTE-006 (3 week), 20151KEYNOTE-002 (10 mg/kg), 20151MDX010 Ipi plus gp100 vs gp100, 20101MDX010 Ipi plus gp100 vs Ipi (EXPLORATORY), 2010gp100 vs. ipilimumab alone ipilimumab alone better 1.52 [1.24; 1.86]1.52 [1.24;1.86]gp100 vs. ipilimumab alone ipilimumab alone better 1.52 [1.24; 1.86]gp100 vs. ipilimumab plus gp100 ipilimumab plus gp100 better 1.47 [1.22; 1.76]1.47 [1.22;1.76]gp100 vs. ipilimumab plus gp100 ipilimumab plus gp100 better 1.47 [1.22; 1.76]gp100 vs. ipilimumab plus SoC ipilimumab plus SoC better 2.27 [1.41; 3.63]2.27 [1.41;3.63]gp100 vs. ipilimumab plus SoC ipilimumab plus SoC better 2.27 [1.41; 3.63]gp100 vs. nivolumab alone nivolumab alone better 1.72 [1.04; 2.84]1.72 [1.04;2.84]gp100 vs. nivolumab alone nivolumab alone better 1.72 [1.04; 2.84]gp100 vs. pembrolizumab (10mg/kg) pembrolizumab (10mg/kg) better 2.20 [1.57; 3.10]2.20 [1.57;3.10]gp100 vs. pembrolizumab (10mg/kg) pembrolizumab (10mg/kg) better 2.20 [1.57; 3.10]gp100 vs. pembrolizumab (10mg/kg) 2 weeks pembrolizumab (10mg/kg) 2 weeks better 2.41 [1.70; 3.42]2.41 [1.70;3.42]gp100 vs. pembrolizumab (10mg/kg) 2 weeks pembrolizumab (10mg/kg) 2 weeks better 2.41 [1.70; 3.42]gp100 vs. pembrolizumab (2mg/kg) pembrolizumab (2mg/kg) better 1.90 [1.16; 3.11]1.90 [1.16;3.11]gp100 vs. pembrolizumab (2mg/kg) pembrolizumab (2mg/kg) better 1.90 [1.16; 3.11]gp100 vs. Standard of Care (SoC) Standard of Care (SoC) better 1.63 [1.06; 2.51]1.63 [1.06;2.51]gp100 vs. Standard of Care (SoC) Standard of Care (SoC) better 1.63 [1.06; 2.51]ipilimumab alone vs. gp100 ipilimumab alone better 0.66 [0.54; 0.81]0.66 [0.54;0.81]ipilimumab alone vs. gp100 ipilimumab alone better 0.66 [0.54; 0.81]ipilimumab alone vs. ipilimumab plus gp100 0.96 [0.80; 1.16]0.96 [0.80;1.16]ipilimumab alone vs. ipilimumab plus gp100 0.96 [0.80; 1.16]ipilimumab alone vs. ipilimumab plus SoC 1.49 [0.97; 2.28]1.49 [0.97;2.28]ipilimumab alone vs. ipilimumab plus SoC 1.49 [0.97; 2.28]ipilimumab alone vs. nivolumab alone 1.13 [0.71; 1.79]1.13 [0.71;1.79]ipilimumab alone vs. nivolumab alone 1.13 [0.71; 1.79]ipilimumab alone vs. pembrolizumab (10mg/kg) pembrolizumab (10mg/kg) better 1.45 [1.10; 1.91]1.45 [1.10;1.91]ipilimumab alone vs. pembrolizumab (10mg/kg) pembrolizumab (10mg/kg) better 1.45 [1.10; 1.91]ipilimumab alone vs. pembrolizumab (10mg/kg) 2 weeks pembrolizumab (10mg/kg) 2 weeks better 1.59 [1.19; 2.11]1.59 [1.19;2.11]ipilimumab alone vs. pembrolizumab (10mg/kg) 2 weeks pembrolizumab (10mg/kg) 2 weeks better 1.59 [1.19; 2.11]ipilimumab alone vs. pembrolizumab (2mg/kg) 1.25 [0.79; 1.96]1.25 [0.79;1.96]ipilimumab alone vs. pembrolizumab (2mg/kg) 1.25 [0.79; 1.96]ipilimumab alone vs. Standard of Care (SoC) 1.07 [0.73; 1.57]1.07 [0.73;1.57]ipilimumab alone vs. Standard of Care (SoC) 1.07 [0.73; 1.57]ipilimumab plus gp100 vs. gp100 ipilimumab plus gp100 better 0.68 [0.57; 0.82]0.68 [0.57;0.82]ipilimumab plus gp100 vs. gp100 ipilimumab plus gp100 better 0.68 [0.57; 0.82]ipilimumab plus gp100 vs. ipilimumab alone 1.04 [0.86; 1.25]1.04 [0.86;1.25]ipilimumab plus gp100 vs. ipilimumab alone 1.04 [0.86; 1.25]ipilimumab plus gp100 vs. ipilimumab plus SoC 1.54 [0.97; 2.46]1.54 [0.97;2.46]ipilimumab plus gp100 vs. ipilimumab plus SoC 1.54 [0.97; 2.46]ipilimumab plus gp100 vs. nivolumab alone 1.17 [0.71; 1.93]1.17 [0.71;1.93]ipilimumab plus gp100 vs. nivolumab alone 1.17 [0.71; 1.93]ipilimumab plus gp100 vs. pembrolizumab (10mg/kg) pembrolizumab (10mg/kg) better 1.50 [1.08; 2.10]1.50 [1.08;2.10]ipilimumab plus gp100 vs. pembrolizumab (10mg/kg) pembrolizumab (10mg/kg) better 1.50 [1.08; 2.10]ipilimumab plus gp100 vs. pembrolizumab (10mg/kg) 2 weeks pembrolizumab (10mg/kg) 2 weeks better 1.65 [1.17; 2.31]1.65 [1.17;2.31]ipilimumab plus gp100 vs. pembrolizumab (10mg/kg) 2 weeks pembrolizumab (10mg/kg) 2 weeks better 1.65 [1.17; 2.31]ipilimumab plus gp100 vs. pembrolizumab (2mg/kg) 1.29 [0.79; 2.11]1.29 [0.79;2.11]ipilimumab plus gp100 vs. pembrolizumab (2mg/kg) 1.29 [0.79; 2.11]ipilimumab plus gp100 vs. Standard of Care (SoC) 1.11 [0.73; 1.70]1.11 [0.73;1.70]ipilimumab plus gp100 vs. Standard of Care (SoC) 1.11 [0.73; 1.70]ipilimumab plus SoC vs. gp100 ipilimumab plus SoC better 0.44 [0.28; 0.71]0.44 [0.28;0.71]ipilimumab plus SoC vs. gp100 ipilimumab plus SoC better 0.44 [0.28; 0.71]ipilimumab plus SoC vs. ipilimumab alone 0.67 [0.44; 1.03]0.67 [0.44;1.03]ipilimumab plus SoC vs. ipilimumab alone 0.67 [0.44; 1.03]ipilimumab plus SoC vs. ipilimumab plus gp100 0.65 [0.41; 1.03]0.65 [0.41;1.03]ipilimumab plus SoC vs. ipilimumab plus gp100 0.65 [0.41; 1.03]ipilimumab plus SoC vs. nivolumab alone 0.76 [0.55; 1.05]0.76 [0.55;1.05]ipilimumab plus SoC vs. nivolumab alone 0.76 [0.55; 1.05]ipilimumab plus SoC vs. pembrolizumab (10mg/kg) 0.97 [0.70; 1.35]0.97 [0.70;1.35]ipilimumab plus SoC vs. pembrolizumab (10mg/kg) 0.97 [0.70; 1.35]ipilimumab plus SoC vs. pembrolizumab (10mg/kg) 2 weeks 1.07 [0.64; 1.78]1.07 [0.64;1.78]ipilimumab plus SoC vs. pembrolizumab (10mg/kg) 2 weeks 1.07 [0.64; 1.78]ipilimumab plus SoC vs. pembrolizumab (2mg/kg) 0.84 [0.61; 1.15]0.84 [0.61;1.15]ipilimumab plus SoC vs. pembrolizumab (2mg/kg) 0.84 [0.61; 1.15]ipilimumab plus SoC vs. Standard of Care (SoC) ipilimumab plus SoC better 0.72 [0.59; 0.87]0.72 [0.59;0.87]ipilimumab plus SoC vs. Standard of Care (SoC) ipilimumab plus SoC better 0.72 [0.59; 0.87]nivolumab alone vs. gp100 nivolumab alone better 0.58 [0.35; 0.96]0.58 [0.35;0.96]nivolumab alone vs. gp100 nivolumab alone better 0.58 [0.35; 0.96]nivolumab alone vs. ipilimumab alone 0.89 [0.56; 1.41]0.89 [0.56;1.41]nivolumab alone vs. ipilimumab alone 0.89 [0.56; 1.41]nivolumab alone vs. ipilimumab plus gp100 0.85 [0.52; 1.41]0.85 [0.52;1.41]nivolumab alone vs. ipilimumab plus gp100 0.85 [0.52; 1.41]nivolumab alone vs. ipilimumab plus SoC 1.32 [0.95; 1.83]1.32 [0.95;1.83]nivolumab alone vs. ipilimumab plus SoC 1.32 [0.95; 1.83]nivolumab alone vs. pembrolizumab (10mg/kg) 1.28 [0.89; 1.86]1.28 [0.89;1.86]nivolumab alone vs. pembrolizumab (10mg/kg) 1.28 [0.89; 1.86]nivolumab alone vs. pembrolizumab (10mg/kg) 2 weeks 1.41 [0.82; 2.42]1.41 [0.82;2.42]nivolumab alone vs. pembrolizumab (10mg/kg) 2 weeks 1.41 [0.82; 2.42]nivolumab alone vs. pembrolizumab (2mg/kg) 1.10 [0.77; 1.59]1.10 [0.77;1.59]nivolumab alone vs. pembrolizumab (2mg/kg) 1.10 [0.77; 1.59]nivolumab alone vs. Standard of Care (SoC) 0.95 [0.73; 1.24]0.95 [0.73;1.24]nivolumab alone vs. Standard of Care (SoC) 0.95 [0.73; 1.24]pembrolizumab (10mg/kg) vs. gp100 pembrolizumab (10mg/kg) better 0.45 [0.32; 0.64]0.45 [0.32;0.64]pembrolizumab (10mg/kg) vs. gp100 pembrolizumab (10mg/kg) better 0.45 [0.32; 0.64]pembrolizumab (10mg/kg) vs. ipilimumab alone pembrolizumab (10mg/kg) better 0.69 [0.52; 0.91]0.69 [0.52;0.91]pembrolizumab (10mg/kg) vs. ipilimumab alone pembrolizumab (10mg/kg) better 0.69 [0.52; 0.91]pembrolizumab (10mg/kg) vs. ipilimumab plus gp100 pembrolizumab (10mg/kg) better 0.67 [0.48; 0.93]0.67 [0.48;0.93]pembrolizumab (10mg/kg) vs. ipilimumab plus gp100 pembrolizumab (10mg/kg) better 0.67 [0.48; 0.93]pembrolizumab (10mg/kg) vs. ipilimumab plus SoC 1.03 [0.74; 1.42]1.03 [0.74;1.42]pembrolizumab (10mg/kg) vs. ipilimumab plus SoC 1.03 [0.74; 1.42]pembrolizumab (10mg/kg) vs. nivolumab alone 0.78 [0.54; 1.13]0.78 [0.54;1.13]pembrolizumab (10mg/kg) vs. nivolumab alone 0.78 [0.54; 1.13]pembrolizumab (10mg/kg) vs. pembrolizumab (10mg/kg) 2 weeks 1.10 [0.74; 1.63]1.10 [0.74;1.63]pembrolizumab (10mg/kg) vs. pembrolizumab (10mg/kg) 2 weeks 1.10 [0.74; 1.63]pembrolizumab (10mg/kg) vs. pembrolizumab (2mg/kg) 0.86 [0.60; 1.23]0.86 [0.60;1.23]pembrolizumab (10mg/kg) vs. pembrolizumab (2mg/kg) 0.86 [0.60; 1.23]pembrolizumab (10mg/kg) vs. Standard of Care (SoC) pembrolizumab (10mg/kg) better 0.74 [0.57; 0.96]0.74 [0.57;0.96]pembrolizumab (10mg/kg) vs. Standard of Care (SoC) pembrolizumab (10mg/kg) better 0.74 [0.57; 0.96]pembrolizumab (10mg/kg) 2 weeks vs. gp100 pembrolizumab (10mg/kg) 2 weeks better 0.41 [0.29; 0.59]0.41 [0.29;0.59]pembrolizumab (10mg/kg) 2 weeks vs. gp100 pembrolizumab (10mg/kg) 2 weeks better 0.41 [0.29; 0.59]pembrolizumab (10mg/kg) 2 weeks vs. ipilimumab alone pembrolizumab (10mg/kg) 2 weeks better 0.63 [0.47; 0.84]0.63 [0.47;0.84]pembrolizumab (10mg/kg) 2 weeks vs. ipilimumab alone pembrolizumab (10mg/kg) 2 weeks better 0.63 [0.47; 0.84]pembrolizumab (10mg/kg) 2 weeks vs. ipilimumab plus gp100 pembrolizumab (10mg/kg) 2 weeks better 0.61 [0.43; 0.85]0.61 [0.43;0.85]pembrolizumab (10mg/kg) 2 weeks vs. ipilimumab plus gp100 pembrolizumab (10mg/kg) 2 weeks better 0.61 [0.43; 0.85]pembrolizumab (10mg/kg) 2 weeks vs. ipilimumab plus SoC 0.94 [0.56; 1.57]0.94 [0.56;1.57]pembrolizumab (10mg/kg) 2 weeks vs. ipilimumab plus SoC 0.94 [0.56; 1.57]pembrolizumab (10mg/kg) 2 weeks vs. nivolumab alone 0.71 [0.41; 1.22]0.71 [0.41;1.22]pembrolizumab (10mg/kg) 2 weeks vs. nivolumab alone 0.71 [0.41; 1.22]pembrolizumab (10mg/kg) 2 weeks vs. pembrolizumab (10mg/kg) 0.91 [0.62; 1.36]0.91 [0.62;1.36]pembrolizumab (10mg/kg) 2 weeks vs. pembrolizumab (10mg/kg) 0.91 [0.62; 1.36]pembrolizumab (10mg/kg) 2 weeks vs. pembrolizumab (2mg/kg) 0.79 [0.46; 1.34]0.79 [0.46;1.34]pembrolizumab (10mg/kg) 2 weeks vs. pembrolizumab (2mg/kg) 0.79 [0.46; 1.34]pembrolizumab (10mg/kg) 2 weeks vs. Standard of Care (SoC) 0.68 [0.42; 1.08]0.68 [0.42;1.08]pembrolizumab (10mg/kg) 2 weeks vs. Standard of Care (SoC) 0.68 [0.42; 1.08]pembrolizumab (2mg/kg) vs. gp100 pembrolizumab (2mg/kg) better 0.53 [0.32; 0.87]0.53 [0.32;0.87]pembrolizumab (2mg/kg) vs. gp100 pembrolizumab (2mg/kg) better 0.53 [0.32; 0.87]pembrolizumab (2mg/kg) vs. ipilimumab alone 0.80 [0.51; 1.26]0.80 [0.51;1.26]pembrolizumab (2mg/kg) vs. ipilimumab alone 0.80 [0.51; 1.26]pembrolizumab (2mg/kg) vs. ipilimumab plus gp100 0.77 [0.47; 1.26]0.77 [0.47;1.26]pembrolizumab (2mg/kg) vs. ipilimumab plus gp100 0.77 [0.47; 1.26]pembrolizumab (2mg/kg) vs. ipilimumab plus SoC 1.19 [0.87; 1.64]1.19 [0.87;1.64]pembrolizumab (2mg/kg) vs. ipilimumab plus SoC 1.19 [0.87; 1.64]pembrolizumab (2mg/kg) vs. nivolumab alone 0.91 [0.63; 1.30]0.91 [0.63;1.30]pembrolizumab (2mg/kg) vs. nivolumab alone 0.91 [0.63; 1.30]pembrolizumab (2mg/kg) vs. pembrolizumab (10mg/kg) 1.16 [0.81; 1.67]1.16 [0.81;1.67]pembrolizumab (2mg/kg) vs. pembrolizumab (10mg/kg) 1.16 [0.81; 1.67]pembrolizumab (2mg/kg) vs. pembrolizumab (10mg/kg) 2 weeks 1.27 [0.75; 2.17]1.27 [0.75;2.17]pembrolizumab (2mg/kg) vs. pembrolizumab (10mg/kg) 2 weeks 1.27 [0.75; 2.17]pembrolizumab (2mg/kg) vs. Standard of Care (SoC) 0.86 [0.67; 1.10]0.86 [0.67;1.10]pembrolizumab (2mg/kg) vs. Standard of Care (SoC) 0.86 [0.67; 1.10]Standard of Care (SoC) vs. gp100 Standard of Care (SoC) better 0.61 [0.40; 0.94]0.61 [0.40;0.94]Standard of Care (SoC) vs. gp100 Standard of Care (SoC) better 0.61 [0.40; 0.94]Standard of Care (SoC) vs. ipilimumab alone 0.93 [0.64; 1.36]0.93 [0.64;1.36]Standard of Care (SoC) vs. ipilimumab alone 0.93 [0.64; 1.36]Standard of Care (SoC) vs. ipilimumab plus gp100 0.90 [0.59; 1.37]0.90 [0.59;1.37]Standard of Care (SoC) vs. ipilimumab plus gp100 0.90 [0.59; 1.37]Standard of Care (SoC) vs. ipilimumab plus SoC ipilimumab plus SoC better 1.39 [1.14; 1.69]1.39 [1.14;1.69]Standard of Care (SoC) vs. ipilimumab plus SoC ipilimumab plus SoC better 1.39 [1.14; 1.69]Standard of Care (SoC) vs. nivolumab alone 1.05 [0.81; 1.37]1.05 [0.81;1.37]Standard of Care (SoC) vs. nivolumab alone 1.05 [0.81; 1.37]Standard of Care (SoC) vs. pembrolizumab (10mg/kg) pembrolizumab (10mg/kg) better 1.35 [1.04; 1.75]1.35 [1.04;1.75]Standard of Care (SoC) vs. pembrolizumab (10mg/kg) pembrolizumab (10mg/kg) better 1.35 [1.04; 1.75]Standard of Care (SoC) vs. pembrolizumab (10mg/kg) 2 weeks 1.48 [0.92; 2.38]1.48 [0.92;2.38]Standard of Care (SoC) vs. pembrolizumab (10mg/kg) 2 weeks 1.48 [0.92; 2.38]Standard of Care (SoC) vs. pembrolizumab (2mg/kg) 1.16 [0.91; 1.49]1.16 [0.91;1.49]Standard of Care (SoC) vs. pembrolizumab (2mg/kg) 1.16 [0.91; 1.49]Standard of Care (SoC)placebo plus SoCipilimumab alonegp100pembrolizumab (2mg/kg)ipilimumab plus SoCnivolumab aloneIpilimumab (10 mg/kg)pembrolizumab (10mg/kg) 2 weekspembrolizumab (10mg/kg)ipilimumab plus gp100direct evidencenetwork meta-analysis
T vs. C Standard of Care (SoC)placebo plus SoCipilimumab alonegp100pembrolizumab (2mg/kg)ipilimumab plus SoCnivolumab aloneIpilimumab (10 mg/kg)pembrolizumab (10mg/kg) 2 weekspembrolizumab (10mg/kg)ipilimumab plus gp100
Standard of Care (SoC)---NA0.93
0.64; 1.36		0.61
0.40; 0.94		1.16
0.91; 1.49		1.39
1.14; 1.69		1.05
0.81; 1.37		NA1.48
0.92; 2.38		1.35
1.04; 1.75		0.90
0.59; 1.37
placebo plus SoCNA---NANANANANANANANANA
ipilimumab alone1.07
0.73; 1.57		NA---0.66
0.54; 0.81		1.25
0.79; 1.96		1.49
0.97; 2.28		1.13
0.71; 1.79		NA1.59
1.19; 2.11		1.45
1.10; 1.91		0.96
0.80; 1.16
gp1001.63
1.06; 2.51		NA1.52
1.24; 1.86		---1.90
1.16; 3.11		2.27
1.41; 3.63		1.72
1.04; 2.84		NA2.41
1.70; 3.42		2.20
1.57; 3.10		1.47
1.22; 1.76
pembrolizumab (2mg/kg)0.86
0.67; 1.10		NA0.80
0.51; 1.26		0.53
0.32; 0.87		---1.19
0.87; 1.64		0.91
0.63; 1.30		NA1.27
0.75; 2.17		1.16
0.81; 1.67		0.77
0.47; 1.26
ipilimumab plus SoC0.72
0.59; 0.87		NA0.67
0.44; 1.03		0.44
0.28; 0.71		0.84
0.61; 1.15		---0.76
0.55; 1.05		NA1.07
0.64; 1.78		0.97
0.70; 1.35		0.65
0.41; 1.03
nivolumab alone0.95
0.73; 1.24		NA0.89
0.56; 1.41		0.58
0.35; 0.96		1.10
0.77; 1.59		1.32
0.95; 1.83		---NA1.41
0.82; 2.42		1.28
0.89; 1.86		0.85
0.52; 1.41
Ipilimumab (10 mg/kg)NANANANANANANA---NANANA
pembrolizumab (10mg/kg) 2 weeks0.68
0.42; 1.08		NA0.63
0.47; 0.84		0.41
0.29; 0.59		0.79
0.46; 1.34		0.94
0.56; 1.57		0.71
0.41; 1.22		NA---0.91
0.62; 1.36		0.61
0.43; 0.85
pembrolizumab (10mg/kg)0.74
0.57; 0.96		NA0.69
0.52; 0.91		0.45
0.32; 0.64		0.86
0.60; 1.23		1.03
0.74; 1.42		0.78
0.54; 1.13		NA1.10
0.74; 1.63		---0.67
0.48; 0.93
ipilimumab plus gp1001.11
0.73; 1.70		NA1.04
0.86; 1.25		0.68
0.57; 0.82		1.29
0.79; 2.11		1.54
0.97; 2.46		1.17
0.71; 1.93		NA1.65
1.17; 2.31		1.50
1.08; 2.10		---

pathologies: 69 - treatments: 549 result logic

 

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