benefit
(statisticaly significant)
benefit (nominaly significant, not statitically demonstrated) NS not significant harm statitically significant NS harm not significant low certainty due to bias
 
deaths (OS)

mML - L1 - all population metastatic/adv melanoma (mML) mML - 1st line (L1) mML - L1 - all population

versus ipilimumab alone
nivolumab alone vs. ipilimumab alone 1 -37%
nivolumab plus ipilimumab vs. ipilimumab alone 2 -42%
versus ipilimumab followed by nivolumab
nivolumab followed by ipilimumab vs. ipilimumab followed by nivolumab 1 -52%
versus nivolumab alone
nivolumab plus ipilimumab vs. nivolumab alone 1 -35%
relatlimab plus nivolumab vs. nivolumab alone 1 -
versus Standard of Care (SoC)
tremelimumab vs. Standard of Care (SoC) 1 NS