meta
|
evidence
oncology
Living systematic review and meta-analysis
multiple myeloma - 2nd line (L2)
1
myofibroblastic tumors
neurofibroma
neutropenia
osteosarcoma
ovarian cancer (OC)
9
immune chekpoint inhibitors
anti-PD-(L)1
atezolizumab based treatment
atezolizumab plus SoC
avelumab based treatment
avelumab alone
avelumab plus pegylated liposomal doxorubicin
avelumab plus SoC
Immune checkpoint association
nivolumab plus ipilimumab
poly ADP-ribose polymerase (PARP) inhibitor
niraparib
olaparib
rucaparib
target therapy
multikinase inhibitor
nintedanib
versus all
vs chemotherapy
vs non platinum-based chemotherapy
vs anthracyclines
vs doxorubicin
vs pegylated liposomal doxorubicin
vs Standard of Care (SoC)
vs placebo plus SoC
vs immune chekpoint inhibitors
vs anti-PD-(L)1
vs nivolumab based treatment
vs nivolumab alone
All patients
Age < 65y (younger)
Age > 65y
Asian type
ECOG ⩾ 1
ECOG 0
ECOG 1
hemoglobin concentration > 10g/dl
PD-L1 < 1%
PD-L1 > 1%
PDL1 (TC0 and IC0 : <1% of TC and IC)
PDL1 (TC1/2 or IC1/2 : ≥1% of TC or IC and <50% of TC and <10% of IC)
PDL1 (TC2/3 or IC2/3 : ≥5% of TC or IC)
stage III (locally advanced)
stage IV (metastatic)
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
study list
mapping
overview
meta-analysis
forest plot
NMA
excluded
button
bars
forest
bayes
pooled
summary
circles
DCR
deaths (OS)
DOR
objective responses (ORR)
progression or deaths (PFS)
AE (any grade)
AE (grade 3-4)
AE leading to death (grade 5)
AE leading to treatment discontinuation (any grade)
SAE (any grade)
STRAE (any grade)
TRAE (any grade)
TRAE (grade 3-4)
TRAE leading to death (grade 5)
TRAE leading to discontinuation (any grade)
Abdominal pain TRAE (grade 3-4)
Acute kidney injury TRAE (grade 3-4)
Adrenal insufficiency TRAE (grade 3-4)
Anaemia TRAE (grade 3-4)
Arthritis TRAE (grade 3-4)
Asthenia TRAE (grade 3-4)
Blood creatinine increased TRAE (grade 3-4)
Colitis TRAE (grade 3-4)
Constipation TRAE (grade 3-4)
Decreased appetite TRAE (grade 3-4)
Diabetes TRAE (grade 3-4)
Diarrhoea TRAE (grade 3-4)
Dry skin TRAE (grade 3-4)
Dyspnoea TRAE (grade 3-4)
Fatigue TRAE (grade 3-4)
Febrile neutropenia TRAE (grade 3-4)
Guillain-Barré syndrome TRAE (grade 3-4)
Hepatitis TRAE (grade 3-4)
Hypersensitivity TRAE (grade 3-4)
Hypertension TRAE (grade 3-4)
Hyperthyroidism TRAE (grade 3-4)
Hypothyroidism TRAE (grade 3-4)
Increase AST TRAE (grade 3-4)
Increased ALT TRAE (grade 3-4)
Increased lipase level TRAE (grade 3-4)
Infusion-related reactions TRAE (grade 3-4)
Leucopenia TRAE (grade 3-4)
Maculopapular rash TRAE (grade 3-4)
Mucosal inflammation TRAE (grade 3-4)
Myocarditis TRAE (grade 3-4)
Myositis TRAE (grade 3-4)
Nausea TRAE (grade 3-4)
Nephritis TRAE (grade 3-4)
Neutropenia TRAE (grade 3-4)
Palmar-plantar erythrodysaesthesia syndrome TRAE (grade 3-4)
Pancreatitis TRAE (grade 3-4)
Pancytopenia TRAE (grade 3-4)
Peripheral neuropathy TRAE (grade 3-4)
Peripheral oedema TRAE (grade 3-4)
Pneumonia TRAE (grade 3-4)
Pneumonitis TRAE (grade 3-4)
Pruritic rash TRAE (grade 3-4)
Pruritus TRAE (grade 3-4)
Pyrexia TRAE (grade 3-4)
Rash TRAE (grade 3-4)
Sepsis TRAE (grade 3-4)
Severe skin reaction TRAE (grade 3-4)
Skin exfoliation TRAE (grade 3-4)
Stomatitis TRAE (grade 3-4)
Thrombocytopenia TRAE (grade 3-4)
Vomiting TRAE (grade 3-4)
Acute kidney injury AE (grade 3-4)
Decreased appetite AE (grade 3-4)
Dyspnoea AE (grade 3-4)
Hypertension AE (grade 3-4)
Infusion-related reaction AE (grade 3-4)
Proteinuria AE (grade 3-4)
deaths (OS)
progression or deaths (PFS)
RFS/DFS
ovarian cancer (OC)
ovarian cancer (OC)
mOC - L1 - all population
metastatic/advanced OC (mOC) - 1st line (L1)
mOC - L1 - all population
versus placebo plus SoC
atezolizumab plus SoC vs. placebo plus SoC
1
-18 [-425; 389]
/10000
109/651 vs. 110/650
-285 [-828; 259]
/10000
323/651 vs. 341/650
-
mOC - L1 - PDL1 positive
metastatic/advanced OC (mOC) - 1st line (L1)
mOC - L1 - PDL1 positive
versus placebo plus SoC
atezolizumab plus SoC vs. placebo plus SoC
1
-43 [-541; 454]
/10000
57/391 vs. 59/393
-793 [-1489; -96]
/10000
167/391 vs. 199/393
-
metastatic/advanced OC (mOC) - 2nd line (L2)
metastatic/advanced OC (mOC) - 2nd line (L2)
versus nivolumab alone
nivolumab plus ipilimumab vs. nivolumab alone
1
-420 [-2369; 1528]
/10000
21/49 vs. 24/51
-1257 [-2605; 92]
/10000
39/49 vs. 47/51
-
versus pegylated liposomal doxorubicin
avelumab alone vs. pegylated liposomal doxorubicin
1
324 [-675; 1324]
/10000
109/188 vs. 104/190
1613 [742; 2483]
/10000
154/188 vs. 125/190
-
avelumab plus pegylated liposomal doxorubicin vs. pegylated liposomal doxorubicin
1
-48 [-1052; 956]
/10000
102/188 vs. 104/190
549 [-386; 1483]
/10000
134/188 vs. 125/190
-
metastatic/advanced OC (mOC) - maintenance (M)
metastatic/advanced OC (mOC) - maintenance (M)
×
delta: difference in rate or median (if available)
×
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