deaths (OS)progression or deaths (PFS)RFS/DFS

laHNSCC - 1st line (L1) locally advanced (laHNSCC) laHNSCC - 1st line (L1)

mHNSCC - L1 - all population metastatic-recurrent HNSCC (mHNSCC) mHNSCC - 1st line (L1) mHNSCC - L1 - all population

versus cetuximab plus platin plus 5FU
pembrolizumab alone vs. cetuximab plus platin plus 5FU 1 NaN [NaN; NaN] /10000
0/0 vs. 0/0
NaN [NaN; NaN] /10000
0/0 vs. 0/0
-

mHNSCC - L1 - PDL1 positive metastatic-recurrent HNSCC (mHNSCC) mHNSCC - 1st line (L1) mHNSCC - L1 - PDL1 positive

versus cetuximab plus platin plus 5FU
pembrolizumab alone vs. cetuximab plus platin plus 5FU 2 NaN [NaN; NaN] /10000
0/0 vs. 0/0
NaN [NaN; NaN] /10000
0/0 vs. 0/0
-

mHNSCC - L2 - all population metastatic-recurrent HNSCC (mHNSCC) mHNSCC - 2nd line (L2) mHNSCC - L2 - all population

versus Standard of Care (SoC)
pembrolizumab alone vs. Standard of Care (SoC) 1 -1019 [-1739; -299] /10000
181/247 vs. 207/248
-206 [-751; 338] /10000
218/247 vs. 224/248
-

mHNSCC - L2 - PDL1 negative metastatic-recurrent HNSCC (mHNSCC) mHNSCC - 2nd line (L2) mHNSCC - L2 - PDL1 negative

mHNSCC - L2 - PDL1 positive metastatic-recurrent HNSCC (mHNSCC) mHNSCC - 2nd line (L2) mHNSCC - L2 - PDL1 positive

versus Standard of Care (SoC)
pembrolizumab alone vs. Standard of Care (SoC) 1 -1441 [-2258; -624] /10000
138/196 vs. 162/191
-681 [-1417; 55] /10000
157/196 vs. 166/191
-