metaEvidence - overview

button bars forest bayes pooled summary circles


			Statistically conclusive or suggested result	Inconclusive results	Uncertain results	Safety results
mUC - L2 - all population metastatic/advanced UC (mUC) - 2nd Line (L2) mUC - L2 - all population
versus Standard of Care (SoC)
	atezolizumab alone vs. Standard of Care (SoC)	1	none	inconclusive results for: progression or deaths (PFS); objective responses (ORR); AE (grade 3-4); AE leading to death (grade 5); SAE (any grade); TRAE leading to death (grade 5)	suggested 15 % decrease in deaths (OS) but the degree if certainty is unassessable suggested 18 % decrease in deaths (OS) (extension) but the degree if certainty is unassessable suggested 84 % decrease in DOR but the degree if certainty is unassessable suggested 62 % decrease in AE (any grade) but the degree if certainty is unassessable suggested 63 % decrease in AE leading to treatment discontinuation (any grade) but the degree if certainty is unassessable suggested 44 % decrease in STRAE (any grade) but the degree if certainty is unassessable suggested 72 % decrease in TRAE (any grade) but the degree if certainty is unassessable suggested 67 % decrease in TRAE (grade 3-4) but the degree if certainty is unassessable suggested 78 % decrease in TRAE leading to discontinuation (any grade) but the degree if certainty is unassessable suggested 60 % decrease in Anaemia TRAE (grade 3-4) but the degree if certainty is unassessable suggested 58 % decrease in Asthenia TRAE (grade 3-4) but the degree if certainty is unassessable suggested 98 % decrease in Constipation TRAE (grade 3-4) but the degree if certainty is unassessable suggested 63 % decrease in Fatigue TRAE (grade 3-4) but the degree if certainty is unassessable suggested 96 % decrease in Febrile neutropenia TRAE (grade 3-4) but the degree if certainty is unassessable suggested 96 % decrease in Neutropenia TRAE (grade 3-4) but the degree if certainty is unassessable suggested 88 % decrease in Peripheral neuropathy TRAE (grade 3-4) but the degree if certainty is unassessable	-

mUC - L2 - all population metastatic/advanced UC (mUC) - 2nd Line (L2) mUC - L2 - all population

versus Standard of Care (SoC)