Statistically conclusive or suggested result Inconclusive results Uncertain results Safety results

mML - L1 - BRAF wild metastatic/adv melanoma (mML) mML - 1st line (L1) mML - L1 - BRAF wild

versus ipilimumab alone
nivolumab plus ipilimumab vs. ipilimumab alone 1 noneinconclusive results for: DOR; TRAE leading to discontinuation (any grade)

statistically conclusive 60 % decrease in progression or deaths (PFS) but the degree if certainty is unassessable

statistically conclusive 13.0-fold increase in objective responses (ORR) but the degree if certainty is unassessable

suggested 13.0-fold increase in objective responses (ORR) (extension) but the degree if certainty is unassessable

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