meta
|
evidence
oncology
Living systematic review and meta-analysis
multiple myeloma - 1st line (L1)
1
immune chekpoint inhibitors
anti-PD-(L)1
pembrolizumab based treatment
pembrolizumab plus lenalidomide and dexamethasone
versus all
vs Immunosuppressant
vs lenalidomide based treatment
vs lenalidomide and dexamethasone
All patients
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
study list
mapping
overview
meta-analysis
forest plot
NMA
excluded
button
bars
forest
bayes
pooled
summary
circles
DCR
deaths (OS)
DOR
objective responses (ORR)
progression or deaths (PFS)
AE (any grade)
AE (grade 3-4)
AE leading to death (grade 5)
AE leading to treatment discontinuation (any grade)
SAE (any grade)
TRAE leading to death (grade 5)
TRAE leading to discontinuation (any grade)
Adrenal insufficiency TRAE (grade 3-4)
Colitis TRAE (grade 3-4)
Diabetes TRAE (grade 3-4)
Dry skin TRAE (grade 3-4)
Hepatitis TRAE (grade 3-4)
Hypersensitivity TRAE (grade 3-4)
Hyperthyroidism TRAE (grade 3-4)
Hypothyroidism TRAE (grade 3-4)
Infusion-related reactions TRAE (grade 3-4)
Myocarditis TRAE (grade 3-4)
Pancreatitis TRAE (grade 3-4)
Pneumonitis TRAE (grade 3-4)
Pruritic rash TRAE (grade 3-4)
Rash TRAE (grade 3-4)
Stevens-Johnson syndrome TRAE (grade 3-4)
Thyroiditis TRAE (grade 3-4)
Anaemia AE (grade 3-4)
Back pain AE (grade 3-4)
Constipation AE (grade 3-4)
Cough AE (grade 3-4)
Decreased appetite AE (grade 3-4)
Diarrhoea AE (grade 3-4)
Dyspnoea AE (grade 3-4)
Fatigue AE (grade 3-4)
Nausea AE (grade 3-4)
Neutropenia AE (grade 3-4)
Peripheral oedema AE (grade 3-4)
Pneumonia AE (grade 3-4)
Pyrexia AE (grade 3-4)
Rash AE (grade 3-4)
Vomiting AE (grade 3-4)
DCR
multiple myeloma - 1st line (L1)
multiple myeloma - 1st line (L1)
versus lenalidomide and dexamethasone
pembrolizumab plus lenalidomide and dexamethasone vs. lenalidomide and dexamethasone
1
1.0
better
0.3
5.0
77 %
×
delta: difference in rate or median (if available)
×
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