deaths (OS)progression or deaths (PFS)RFS/DFS

mML - NA - all population metastatic/adv melanoma (mML) mML - (neo)adjuvant (NA) mML - NA - all population

versus placebo
pembrolizumab alone vs. placebo 1 --1.0better0.35.0100 %

mML - NA - PDL1 positive metastatic/adv melanoma (mML) mML - (neo)adjuvant (NA) mML - NA - PDL1 positive

versus placebo
pembrolizumab alone vs. placebo 1 --1.0better0.35.0100 %

mML - L1 - all population metastatic/adv melanoma (mML) mML - 1st line (L1) mML - L1 - all population

mML - L1 - BRAF mutant metastatic/adv melanoma (mML) mML - 1st line (L1) mML - L1 - BRAF mutant

mML - L1 - BRAF wild metastatic/adv melanoma (mML) mML - 1st line (L1) mML - L1 - BRAF wild

mML - L2 - all population metastatic/adv melanoma (mML) mML - 2nd line (L2) mML - L2 - all population

versus ipilimumab alone
pembrolizumab (10mg/kg) vs. ipilimumab alone 1 1.0better0.35.0100 %1.0better0.35.0100 %-
pembrolizumab (10mg/kg) 2 weeks vs. ipilimumab alone 1 1.0better0.35.0100 %1.0better0.35.0100 %-
versus Standard of Care (SoC)
pembrolizumab (10mg/kg) vs. Standard of Care (SoC) 1 1.0better0.35.099 %1.0better0.35.0100 %-
pembrolizumab (2mg/kg) vs. Standard of Care (SoC) 1 1.0better0.35.088 %1.0better0.35.0100 %-

mML - L2 - BRAF mutant metastatic/adv melanoma (mML) mML - 2nd line (L2) mML - L2 - BRAF mutant

versus placebo plus SoC
pembrolizumab plus SoC vs. placebo plus SoC 1 1.0better0.35.081 %1.0better0.35.095 %-