deaths (OS)progression or deaths (PFS)RFS/DFS

mML - NA - all population metastatic/adv melanoma (mML) mML - (neo)adjuvant (NA) mML - NA - all population

versus interferon alpha
Ipilimumab (10 mg/kg) vs. interferon alpha 1 0.880.84
ipilimumab alone vs. interferon alpha 1 0.830.85
versus placebo
Ipilimumab (10 mg/kg) vs. placebo 1 0.720.75

mML - NA - PDL1 positive metastatic/adv melanoma (mML) mML - (neo)adjuvant (NA) mML - NA - PDL1 positive

mML - L1 - all population metastatic/adv melanoma (mML) mML - 1st line (L1) mML - L1 - all population

versus Standard of Care (SoC)
tremelimumab vs. Standard of Care (SoC) 1 0.88

mML - L1 - BRAF mutant metastatic/adv melanoma (mML) mML - 1st line (L1) mML - L1 - BRAF mutant

mML - L1 - BRAF wild metastatic/adv melanoma (mML) mML - 1st line (L1) mML - L1 - BRAF wild

mML - L2 - all population metastatic/adv melanoma (mML) mML - 2nd line (L2) mML - L2 - all population

versus gp100
ipilimumab alone vs. gp100 1 0.66
ipilimumab plus gp100 vs. gp100 1 0.68
versus ipilimumab alone
Ipilimumab (10 mg/kg) vs. ipilimumab alone 1 0.840.89
ipilimumab plus gp100 vs. ipilimumab alone 1 1.04
versus placebo plus SoC
ipilimumab plus SoC vs. placebo plus SoC 1 0.720.76

mML - L2 - BRAF mutant metastatic/adv melanoma (mML) mML - 2nd line (L2) mML - L2 - BRAF mutant