deaths (OS)

mML - L1 - all population metastatic/adv melanoma (mML) mML - 1st line (L1) mML - L1 - all population

versus ipilimumab alone
nivolumab alone vs. ipilimumab alone 1 0.63 [0.48; 0.82], 1 RCT, I2=0% conclusive
unassessable degree of certainty
nivolumab plus ipilimumab vs. ipilimumab alone 2 0.58 [0.46; 0.74], 2 RCTs, I2=0% conclusive
high degree of certainty
versus ipilimumab followed by nivolumab
nivolumab followed by ipilimumab vs. ipilimumab followed by nivolumab 1 0.48 [0.29; 0.80], 1 RCT, I2=0%
unassessable degree of certainty
versus nivolumab alone
nivolumab plus ipilimumab vs. nivolumab alone 1 0.65 [0.53; 0.80], 1 RCT, I2=0%
unassessable degree of certainty
relatlimab plus nivolumab vs. nivolumab alone 1 -
versus Standard of Care (SoC)
tremelimumab vs. Standard of Care (SoC) 1 0.88 [0.75; 1.04], 1 RCT, I2=0%
inconclusive result