deaths (OS)

mML - L2 - all population metastatic/adv melanoma (mML) mML - 2nd line (L2) mML - L2 - all population

versus ipilimumab alone
pembrolizumab (10mg/kg) vs. ipilimumab alone 1 0.69 [0.52; 0.91], 1 RCT, I2=0% conclusive
unassessable degree of certainty
pembrolizumab (10mg/kg) 2 weeks vs. ipilimumab alone 1 0.63 [0.47; 0.84], 1 RCT, I2=0% conclusive
unassessable degree of certainty
versus Standard of Care (SoC)
pembrolizumab (10mg/kg) vs. Standard of Care (SoC) 1 0.74 [0.57; 0.96], 1 RCT, I2=0%
unassessable degree of certainty
pembrolizumab (2mg/kg) vs. Standard of Care (SoC) 1 0.86 [0.67; 1.10], 1 RCT, I2=0%
inconclusive result

mML - L2 - BRAF mutant metastatic/adv melanoma (mML) mML - 2nd line (L2) mML - L2 - BRAF mutant

versus placebo plus SoC
pembrolizumab plus SoC vs. placebo plus SoC 1 0.76 [0.41; 1.40], 1 RCT, I2=0%
inconclusive result