deaths (OS)progression or deaths (PFS)RFS/DFS

mNSCLC - L1 - all population metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) mNSCLC - L1 - all population

versus placebo plus SoC
sintillimab plus SoC vs. placebo plus SoC 1 0.61 [0.40; 0.93], 1 RCT, I2=0%
unassessable degree of certainty
0.48 [0.36; 0.64], 1 RCT, I2=0% conclusive
unassessable degree of certainty
-
versus Standard of Care (SoC)
cemiplimab vs. Standard of Care (SoC) 1 0.68 [0.53; 0.87], 1 RCT, I2=0% conclusive
unassessable degree of certainty
0.59 [0.49; 0.72], 1 RCT, I2=0% conclusive
unassessable degree of certainty
-
durvalumab alone vs. Standard of Care (SoC) 1 0.96 [0.81; 1.13], 1 RCT, I2=0%
inconclusive result
--
durvalumab plus tremelimumab vs. Standard of Care (SoC) 1 0.94 [0.80; 1.11], 1 RCT, I2=0%
inconclusive result
--
nivolumab plus ipilimumab plus SoC vs. Standard of Care (SoC) 1 0.69 [0.55; 0.87], 1 RCT, I2=0% conclusive
unassessable degree of certainty
0.70 [0.57; 0.86], 1 RCT, I2=0% conclusive
unassessable degree of certainty
-