button bars forest bayes pooled summary circles
 
deaths (OS)progression or deaths (PFS)RFS/DFS

la/mBC - HER2 positive - 1st Line (L1) breast cancer - HER2-positive la/mBC - HER2 positive la/mBC - HER2 positive - 1st Line (L1)

versus trastuzumab
pertuzumab plus trastuzumab vs. trastuzumab 1 - 0.65 [0.48; 0.89], 1 RCT, I2=0% conclusive
unassessable degree of certainty		-
versus trastuzumab plus chemotherapy
trastuzumab plus endocrine therapy vs. trastuzumab plus chemotherapy 1 0.82 [0.65; 1.04], 1 RCT, I2=0%
inconclusive result		 0.88 [0.71; 1.09], 1 RCT, I2=0%
inconclusive result		-
versus trastuzumab plus docetaxel
pertuzumab plus trastuzumab plus docetaxel vs. trastuzumab plus docetaxel 2 0.66 [0.52; 0.84], 1 RCT, I2=0% conclusive
unassessable degree of certainty		 0.64 [0.54; 0.75], 2 RCTs, I2=0% conclusive
high degree of certainty		-

la/mBC - HER2 positive - 2nd Line (L2) breast cancer - HER2-positive la/mBC - HER2 positive la/mBC - HER2 positive - 2nd Line (L2)

versus lapatinib
lapatinib plus trastuzumab vs. lapatinib 1 0.74 [0.57; 0.96], 1 RCT, I2=0%
unassessable degree of certainty		 0.74 [0.58; 0.94], 1 RCT, I2=0%
unassessable degree of certainty		-
versus lapatinib plus capecitabine
neratinib plus capecitabine vs. lapatinib plus capecitabine 2 0.88 [0.74; 1.06], 2 RCTs, I2=0%
inconclusive result		 0.74 [0.62; 0.89], 2 RCTs, I2=0% conclusive
moderate degree of certainty		-
versus placebo
neratinib vs. placebo 1 ---
versus trastuzumab plus capecitabine
lapatinib plus capecitabine vs. trastuzumab plus capecitabine 1 0.58 [0.26; 1.30], 1 RCT, I2=0%
inconclusive result		 0.81 [0.55; 1.20], 1 RCT, I2=0%
inconclusive result		-
tucatinib plus trastuzumab plus capecitabine vs. trastuzumab plus capecitabine 2 0.66 [0.50; 0.88], 1 RCT, I2=0% conclusive
unassessable degree of certainty		 0.54 [0.42; 0.70], 1 RCT, I2=0% conclusive
unassessable degree of certainty		-
versus trastuzumab plus vinorelbine
afatinib plus vinorelbine vs. trastuzumab plus vinorelbine 1 1.48 [1.12; 1.95], 1 RCT, I2=0%
statistically significant harm		 1.10 [0.86; 1.41], 1 RCT, I2=0%
inconclusive result		-

 

- About us - Contact us - Method - RSS Made with in Lyon - Credits - Privacy policy - Licence Creative Commons