meta
|
evidence
oncology
Living systematic review and meta-analysis
metastatic, hormone-sensitive prostate cancer
11
renal cell cancer (RCC)
immune chekpoint inhibitors
anti-PD-(L)1
atezolizumab based treatment
atezolizumab alone
atezolizumab plus bevacizumab
avelumab based treatment
avelumab plus axitinib
nivolumab based treatment
nivolumab alone
nivolumab plus cabozantinib
pembrolizumab based treatment
pembrolizumab alone
pembrolizumab plus axitinib
pembrolizumab plus lenvatinib
Immune checkpoint association
nivolumab plus ipilimumab
mTOR inhibitors
everolimus
lenvatinib plus everolimus
VEGF(R) inhibitor
lenvatinib
lenvatinib in association
versus all
vs immune chekpoint inhibitors
vs Immune checkpoint association
vs nivolumab plus ipilimumab
vs mTOR inhibitors
vs everolimus
vs non active control
vs placebo
vs VEGF(R) inhibitor
vs sunitinib
All patients
metastasis (liver )
previous nephrectomy (no)
previous nephrectomy (yes)
Risk favorable (IMDC)
Risk favorable (MSKCC)
Risk intermediate (IMDC)
Risk intermediate (MSKCC)
Risk poor (IMDC)
Risk poor (MSKCC)
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
study list
mapping
overview
meta-analysis
forest plot
NMA
excluded
button
bars
forest
bayes
pooled
summary
circles
deaths (OS)
DOR
objective responses (ORR)
progression or deaths (PFS)
AE (any grade)
AE (grade 3-4)
AE leading to death (grade 5)
TRAE (any grade)
TRAE (grade 3-4)
TRAE leading to death (grade 5)
TRAE leading to discontinuation (any grade)
Adrenal insufficiency TRAE (grade 3-4)
Anaemia TRAE (grade 3-4)
Arthralgia TRAE (grade 3-4)
Colitis TRAE (grade 3-4)
Decreased appetite TRAE (grade 3-4)
Diarrhoea TRAE (grade 3-4)
Dysgeusia TRAE (grade 3-4)
Dyspepsia TRAE (grade 3-4)
Dysphonia TRAE (grade 3-4)
Epistaxis TRAE (grade 3-4)
Fatigue TRAE (grade 3-4)
Headache TRAE (grade 3-4)
Hypertension TRAE (grade 3-4)
Hyperthyroidism TRAE (grade 3-4)
Hypothyroidism TRAE (grade 3-4)
Mucosal inflammation TRAE (grade 3-4)
Nausea TRAE (grade 3-4)
Neutropenia TRAE (grade 3-4)
Palmar-plantar erythrodysaesthesia syndrome TRAE (grade 3-4)
Pneumonitis TRAE (grade 3-4)
Proteinuria TRAE (grade 3-4)
Pruritus TRAE (grade 3-4)
Rash TRAE (grade 3-4)
Stomatitis TRAE (grade 3-4)
Thrombocytopenia TRAE (grade 3-4)
Vomiting TRAE (grade 3-4)
deaths (OS)
progression or deaths (PFS)
RFS/DFS
metastatic/advanced RCC (mRCC) - (neo)adjuvant(NA)
metastatic/advanced RCC (mRCC) - (neo)adjuvant(NA)
metastatic/advanced RCC (mRCC) - 1st line (L1)
metastatic/advanced RCC (mRCC) - 1st line (L1)
versus sunitinib
atezolizumab alone vs. sunitinib
1
-
1.19
[0.82; 1.72], 1 RCT, I2=0%
inconclusive result
-
atezolizumab plus bevacizumab vs. sunitinib
2
0.93
[0.76; 1.14], 1 RCT, I2=0%
inconclusive result
0.90
[0.77; 1.05], 2 RCTs, I2=0%
inconclusive result
-
mRCC - L1 - PDL1 negative
metastatic/advanced RCC (mRCC) - 1st line (L1)
mRCC - L1 - PDL1 negative
versus sunitinib
atezolizumab plus bevacizumab vs. sunitinib
1
-
0.84
[0.67; 1.05], 1 RCT, I2=0%
inconclusive result
-
mRCC - L1 - PDL1 positive
metastatic/advanced RCC (mRCC) - 1st line (L1)
mRCC - L1 - PDL1 positive
versus sunitinib
atezolizumab alone vs. sunitinib
1
-
1.03
[0.63; 1.68], 1 RCT, I2=0%
inconclusive result
-
atezolizumab plus bevacizumab vs. sunitinib
2
0.84
[0.62; 1.14], 1 RCT, I2=0%
inconclusive result
0.83
[0.59; 1.16], 2 RCTs, I2=37%
inconclusive result
-
metastatic/advanced RCC (mRCC) - 2nd line (L2)
metastatic/advanced RCC (mRCC) - 2nd line (L2)
×
delta: difference in rate or median (if available)
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