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| deaths (OS) | progression or deaths (PFS) | RFS/DFS |
metastatic/advanced RCC (mRCC) - (neo)adjuvant(NA) metastatic/advanced RCC (mRCC) - (neo)adjuvant(NA) |
|
| pembrolizumab alone vs. placebo | 1 | 0.54 [0.30; 0.97], 1 RCT, I2=0%
unassessable degree of certainty | - | 0.68 [0.53; 0.87], 1 RCT, I2=0% conclusive
unassessable degree of certainty |
metastatic/advanced RCC (mRCC) - 1st line (L1) metastatic/advanced RCC (mRCC) - 1st line (L1) |
|
| atezolizumab alone vs. sunitinib | 1 | - | 1.19 [0.82; 1.72], 1 RCT, I2=0%
inconclusive result | - |
| atezolizumab plus bevacizumab vs. sunitinib | 2 | 0.93 [0.76; 1.14], 1 RCT, I2=0%
inconclusive result | 0.90 [0.77; 1.05], 2 RCTs, I2=0%
inconclusive result | - |
| avelumab plus axitinib vs. sunitinib | 1 | 0.80 [0.62; 1.03], 1 RCT, I2=0%
inconclusive result | 0.69 [0.56; 0.85], 1 RCT, I2=0% conclusive
unassessable degree of certainty | - |
| nivolumab plus cabozantinib vs. sunitinib | 1 | 0.60 [0.40; 0.89], 1 RCT, I2=0% conclusive
unassessable degree of certainty | 0.51 [0.41; 0.64], 1 RCT, I2=0% conclusive
unassessable degree of certainty | - |
| nivolumab plus ipilimumab vs. sunitinib | 3 | 0.68 [0.49; 0.95], 1 RCT, I2=0%
unassessable degree of certainty | 0.98 [0.79; 1.22], 1 RCT, I2=0%
inconclusive result | - |
| pembrolizumab plus axitinib vs. sunitinib | 1 | 0.53 [0.38; 0.74], 1 RCT, I2=0% conclusive
unassessable degree of certainty | 0.69 [0.57; 0.84], 1 RCT, I2=0% conclusive
unassessable degree of certainty | - |
| pembrolizumab plus lenvatinib vs. sunitinib | 1 | 0.66 [0.49; 0.88], 1 RCT, I2=0% conclusive
unassessable degree of certainty | 0.39 [0.32; 0.48], 1 RCT, I2=0% conclusive
unassessable degree of certainty | - |
mRCC - L1 - PDL1 negative metastatic/advanced RCC (mRCC) - 1st line (L1) mRCC - L1 - PDL1 negative |
|
| atezolizumab plus bevacizumab vs. sunitinib | 1 | - | 0.84 [0.67; 1.05], 1 RCT, I2=0%
inconclusive result | - |
mRCC - L1 - PDL1 positive metastatic/advanced RCC (mRCC) - 1st line (L1) mRCC - L1 - PDL1 positive |
|
| atezolizumab alone vs. sunitinib | 1 | - | 1.03 [0.63; 1.68], 1 RCT, I2=0%
inconclusive result | - |
| atezolizumab plus bevacizumab vs. sunitinib | 2 | 0.84 [0.62; 1.14], 1 RCT, I2=0%
inconclusive result | 0.83 [0.59; 1.16], 2 RCTs, I2=37%
inconclusive result | - |
| avelumab plus axitinib vs. sunitinib | 1 | 0.69 [0.58; 0.83], 1 RCT, I2=0%
unassessable degree of certainty | 0.61 [0.47; 0.79], 1 RCT, I2=0% conclusive
unassessable degree of certainty | - |
metastatic/advanced RCC (mRCC) - 2nd line (L2) metastatic/advanced RCC (mRCC) - 2nd line (L2) |
|
| nivolumab alone vs. everolimus | 1 | 0.73 [0.57; 0.93], 1 RCT, I2=0% conclusive
unassessable degree of certainty | 0.88 [0.75; 1.03], 1 RCT, I2=0%
inconclusive result | - |
