meta
|
evidence
oncology
Living systematic review and meta-analysis
metastatic, hormone-sensitive prostate cancer
11
renal cell cancer (RCC)
immune chekpoint inhibitors
anti-PD-(L)1
atezolizumab based treatment
atezolizumab alone
atezolizumab plus bevacizumab
atezolizumab plus cabozantinib
avelumab based treatment
avelumab plus axitinib
nivolumab based treatment
nivolumab alone
nivolumab plus cabozantinib
pembrolizumab based treatment
pembrolizumab alone
pembrolizumab plus axitinib
pembrolizumab plus lenvatinib
Immune checkpoint association
nivolumab plus ipilimumab
mTOR inhibitors
everolimus
lenvatinib plus everolimus
VEGF(R) inhibitor
lenvatinib
lenvatinib in association
versus all
vs immune chekpoint inhibitors
vs Immune checkpoint association
vs nivolumab plus ipilimumab
vs mTOR inhibitors
vs everolimus
vs non active control
vs placebo
vs VEGF(R) inhibitor
vs cabozantinib
vs sunitinib
All patients
Age < 65y (younger)
Age > 65y
Age > 75y (older)
ECOG 0
ECOG 1
Gender, female
Gender, male
metastasis (bone)
metastasis (liver )
metastasis (lung)
metastasis (lymph node )
PD-L1 < 1%
PD-L1 > 1%
PD-L1 > 5%
PDL1 (CPS < 1)
PDL1 (CPS >1)
previous nephrectomy (no)
previous nephrectomy (yes)
Risk favorable (IMDC)
Risk favorable (MSKCC)
Risk intermediate (IMDC)
Risk intermediate (MSKCC)
Risk poor (IMDC)
Risk poor (MSKCC)
smoker (current or former)
smoker (never)
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
study list
mapping
overview
meta-analysis
forest plot
NMA
excluded
button
bars
forest
bayes
pooled
summary
circles
deaths (OS)
deaths (OS) (extension)
DOR
DOR (extension)
objective responses (ORR)
objective responses (ORR) (extension)
PFS (extension)
progression or deaths (PFS)
RFS/DFS
AE (any grade)
AE (grade 3-4)
AE leading to death (grade 5)
AE leading to treatment discontinuation (any grade)
SAE (any grade)
TRAE (any grade)
TRAE (grade 3-4)
TRAE leading to death (grade 5)
TRAE leading to discontinuation (any grade)
Acute kidney injury TRAE (grade 3-4)
Adrenal insufficiency TRAE (grade 3-4)
Anaemia TRAE (grade 3-4)
Arthralgia TRAE (grade 3-4)
Asthenia TRAE (grade 3-4)
Blister TRAE (grade 3-4)
Blood creatinine increased TRAE (grade 3-4)
Chills TRAE (grade 3-4)
Colitis TRAE (grade 3-4)
Cough TRAE (grade 3-4)
Decreased appetite TRAE (grade 3-4)
Diabetes TRAE (grade 3-4)
Diarrhoea TRAE (grade 3-4)
Dysgeusia TRAE (grade 3-4)
Dyspepsia TRAE (grade 3-4)
Dysphonia TRAE (grade 3-4)
Dyspnoea TRAE (grade 3-4)
Eczema TRAE (grade 3-4)
Endocrine disorders TRAE (grade 3-4)
Epistaxis TRAE (grade 3-4)
Erythema TRAE (grade 3-4)
Fatigue TRAE (grade 3-4)
Gastrointestinal disorders TRAE (grade 3-4)
Headache TRAE (grade 3-4)
Hepatitis TRAE (grade 3-4)
Hepatobiliary disorders TRAE (grade 3-4)
Hypertension TRAE (grade 3-4)
Hyperthyroidism TRAE (grade 3-4)
Hypophysitis TRAE (grade 3-4)
Hypothyroidism TRAE (grade 3-4)
Increase AST TRAE (grade 3-4)
Increased ALT TRAE (grade 3-4)
Increased lipase level TRAE (grade 3-4)
Infusion-related reactions TRAE (grade 3-4)
Maculopapular rash TRAE (grade 3-4)
Mucosal inflammation TRAE (grade 3-4)
Myocarditis TRAE (grade 3-4)
Myositis TRAE (grade 3-4)
Nausea TRAE (grade 3-4)
Nephritis TRAE (grade 3-4)
Neutropenia TRAE (grade 3-4)
Palmar-plantar erythrodysaesthesia syndrome TRAE (grade 3-4)
Pancreatitis TRAE (grade 3-4)
Peripheral oedema TRAE (grade 3-4)
Pneumonitis TRAE (grade 3-4)
Proteinuria TRAE (grade 3-4)
Pruritic rash TRAE (grade 3-4)
Pruritus generalised TRAE (grade 3-4)
Pruritus TRAE (grade 3-4)
Rash TRAE (grade 3-4)
Renal and urinary disorders TRAE (grade 3-4)
Respiratory, thoracic and mediastinal disorders TRAE (grade 3-4)
Severe skin reaction TRAE (grade 3-4)
Skin and subcutaneous tissue disorders TRAE (grade 3-4)
Skin exfoliation TRAE (grade 3-4)
Skin hypopigmentation TRAE (grade 3-4)
Stomatitis TRAE (grade 3-4)
Thrombocytopenia TRAE (grade 3-4)
Thyroiditis TRAE (grade 3-4)
Urticaria TRAE (grade 3-4)
Uveitis TRAE (grade 3-4)
Vomiting TRAE (grade 3-4)
Weight decreased TRAE (grade 3-4)
Abdominal pain AE (grade 3-4)
Anaemia AE (grade 3-4)
Arthralgia AE (grade 3-4)
Asthenia AE (grade 3-4)
Back pain AE (grade 3-4)
Blood creatinine increased AE (grade 3-4)
Chills AE (grade 3-4)
Constipation AE (grade 3-4)
Cough AE (grade 3-4)
Decreased appetite AE (grade 3-4)
Diarrhoea AE (grade 3-4)
Dizziness AE (grade 3-4)
Dry skin AE (grade 3-4)
Dysgeusia AE (grade 3-4)
Dyspepsia AE (grade 3-4)
Dysphonia AE (grade 3-4)
Dyspnoea AE (grade 3-4)
Epistaxis AE (grade 3-4)
Fatigue AE (grade 3-4)
Headache AE (grade 3-4)
Hypertension AE (grade 3-4)
Hyperthyroidism AE (grade 3-4)
Hypothyroidism AE (grade 3-4)
Increase AST AE (grade 3-4)
Increased ALT AE (grade 3-4)
Mucosal inflammation AE (grade 3-4)
Nausea AE (grade 3-4)
Neutropenia AE (grade 3-4)
Oropharyngeal pain AE (grade 3-4)
Palmar–plantar erythrodysesthesia syndrome AE (grade 3-4)
Peripheral oedema AE (grade 3-4)
Proteinuria AE (grade 3-4)
Pruritus AE (grade 3-4)
Pyrexia AE (grade 3-4)
Rash AE (grade 3-4)
Stomatitis AE (grade 3-4)
Thrombocytopenia AE (grade 3-4)
Vomiting AE (grade 3-4)
Weight decreased AE (grade 3-4)
deaths (OS)
metastatic/advanced RCC (mRCC) - (neo)adjuvant(NA)
metastatic/advanced RCC (mRCC) - (neo)adjuvant(NA)
versus placebo
pembrolizumab alone vs. placebo
1
certainty unassessable
-42%
metastatic/advanced RCC (mRCC) - 1st line (L1)
metastatic/advanced RCC (mRCC) - 1st line (L1)
versus sunitinib
atezolizumab alone vs. sunitinib
1
-
atezolizumab plus bevacizumab vs. sunitinib
2
certainty unassessable
-6%
avelumab plus axitinib vs. sunitinib
1
certainty unassessable
-18%
nivolumab plus cabozantinib vs. sunitinib
1
certainty unassessable
statistically conclusive
-37%
nivolumab plus ipilimumab vs. sunitinib
3
certainty unassessable
-29%
pembrolizumab plus axitinib vs. sunitinib
1
certainty unassessable
statistically conclusive
-43%
pembrolizumab plus lenvatinib vs. sunitinib
1
certainty unassessable
statistically conclusive
-31%
mRCC - L1 - PDL1 negative
metastatic/advanced RCC (mRCC) - 1st line (L1)
mRCC - L1 - PDL1 negative
versus sunitinib
atezolizumab plus bevacizumab vs. sunitinib
1
-
mRCC - L1 - PDL1 positive
metastatic/advanced RCC (mRCC) - 1st line (L1)
mRCC - L1 - PDL1 positive
versus sunitinib
atezolizumab alone vs. sunitinib
1
-
atezolizumab plus bevacizumab vs. sunitinib
2
certainty unassessable
-15%
avelumab plus axitinib vs. sunitinib
1
certainty unassessable
-29%
metastatic/advanced RCC (mRCC) - 2nd line (L2)
metastatic/advanced RCC (mRCC) - 2nd line (L2)
versus cabozantinib
atezolizumab plus cabozantinib vs. cabozantinib
1
certainty unassessable
-6%
versus everolimus
nivolumab alone vs. everolimus
1
certainty unassessable
statistically conclusive
-25%
×
delta: difference in rate or median (if available)
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