deaths (OS)progression or deaths (PFS)RFS/DFS

la/mBC - HER2 positive - 1st Line (L1) breast cancer - HER2-positive la/mBC - HER2 positive la/mBC - HER2 positive - 1st Line (L1)

la/mBC - HER2 positive - 2nd Line (L2) breast cancer - HER2-positive la/mBC - HER2 positive la/mBC - HER2 positive - 2nd Line (L2)

versus lapatinib
lapatinib plus trastuzumab vs. lapatinib 1 certainty unassessable-24% certainty unassessable-24%-
versus trastuzumab plus capecitabine
lapatinib plus capecitabine vs. trastuzumab plus capecitabine 1 certainty unassessable-39% certainty unassessable-17%-