Study explorer (study characteristics and results) method abbreviations pdf   xlsx

display ongoing studies
Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID-19 mild to moderate meta-analysis

FACCT Trial
  NCT04392973		 RCThydroxychloroquinestandard of careCOVID-19 mild to moderatesome concern
125/129 inconclusive
  • inconclusive 15 % decrease in clinical improvement (time to event analysis only) (PE) with a moderate degree of certainty due to some concern in risk of bias
Coalition Covid-19 Brazil I (Cavalcanti)-Hydroxychloroquine
  NCT04322123		 RCThydroxychloroquinestandard of careCOVID-19 mild to moderatesome concern
221/227 safety concern
  • statistically significant 74 % increase in adverse events with a moderate degree of certainty due to some concern in risk of bias
HC-nCoV (Shanghai)
  NCT04261517		 RCThydroxychloroquinestandard of careCOVID-19 mild to moderatehigh
15/15 inconclusive
    Kamran
          NCT04491994    		 RCThydroxychloroquinestandard of careCOVID-19 mild to moderatehigh
    		360/180 inconclusive
    • inconclusive 5 % decrease in clinical deterioration (PE) but with a low degree of certainty due to high risk of bias
    NCT04333654
          NCT04333654    		 RCThydroxychloroquinestandard of careCOVID-19 mild to moderateNA
    		-/- inconclusive
      NCT04342650
              NCT04342650      		 RCTchloroquineplaceboCOVID-19 mild to moderateNA
      		-/- inconclusive
        Zhaowei Chen
                  ChiCTR2000029559        		 RCThydroxychloroquinecontrolCOVID-19 mild to moderatehigh
        		31/31 inconclusive
          Zhaowei Chen
                      ChiCTR2000029559          		 RCThydroxychloroquinestandard of careCOVID-19 mild to moderatehigh
          		31/31 suggested
          • suggested 2.4-fold increase in radiologic improvement (7-day) but with a low degree of certainty due to high risk of bias
          • suggested 2.4-fold increase in radiologic improvement (7-day) but with a low degree of certainty due to high risk of bias
          1 study excluded by filtering options (0 RCT / 1 OBS)

          PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
          Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

           

          - About us - Contact us - Method - RSS Made with in Lyon - Credits - Privacy policy - Licence Creative Commons