Study explorer (study characteristics and results) method abbreviations pdf   xlsx

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Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID-19 prophylaxis (children) meta-analysis

C4591001 (Adolescents 12-25)
 
NCT04368728
RCTComirnaty (tozinameran - Pfizer/BIONTECH)controlCOVID-19 prophylaxis (children)some concern
1134/1130 suggested
  • suggested 92 % decrease in confirmed Covid-19, from 1st dose with a moderate degree of certainty due to some concern in risk of bias
  • suggested 97 % decrease in symptomatic Covid-19 with a moderate degree of certainty due to some concern in risk of bias
11 studies excluded by filtering options (1 RCT / 10 OBS)

PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).