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Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID-19 mild to moderate meta-analysis

Li T, 2020
 
NCT04273763
RCTbromhexinestandard of careCOVID-19 mild to moderatesome concern
12/6 safety concern
  • inconclusive 52 % decrease in clinical deterioration (PE) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 9.0-fold increase in hospital discharge with a moderate degree of certainty due to some concern in risk of bias
  • statistically significant 1,000 % decrease in recovery (PE) with a moderate degree of certainty due to some concern in risk of bias
2 studies excluded by filtering options (2 RCT / 0 OBS)

PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).