Study explorer (study characteristics and results) method abbreviations pdf   xlsx

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Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 hospitalized meta-analysis

Baldeon
 
SRCTN85216856
RCTconvalescent plasma treatmentplaceboCOVID 19 hospitalizedsome concern
63/95 inconclusive
    ITAC
     
    NCT04546581
    RCTneutralizing antibodyplaceboCOVID 19 hospitalizedsome concern
    301/292 inconclusive
    • inconclusive 6 % increase in clinical improvement,clinical improvement (7-day) (PE) with a moderate degree of certainty due to some concern in risk of bias
    trial did not meet its endpoints (press release)
    ASCOT
     
    NCT04483960
    RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedlow
    15/18 inconclusive
      Bennett-Guerrero
       
      NCT04344535
      RCTconvalescent plasma treatmentplaceboCOVID 19 hospitalizedsome concern
      59/15 inconclusive
        CCAP-2
         
        NCT04345289
        RCTconvalescent plasma treatmentplaceboCOVID 19 hospitalizedlow
        98/46 inconclusive
          Co-CLARITY
           
          NCT04567173
          RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedlow
          13/12 inconclusive
            CONCOR-1
             
            NCT04348656
            RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
            625/313 safety concern
            • inconclusive 16 % increase in death or ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
            • statistically significant 27 % increase in serious adverse events with a moderate degree of certainty due to some concern in risk of bias
            CONTAIN COVID-19
             
            NCT04364737
            RCTconvalescent plasma treatmentplaceboCOVID 19 hospitalizedsome concern
            468/473 inconclusive
            • inconclusive 6 % decrease in clinical deterioration (PE) with a moderate degree of certainty due to some concern in risk of bias
            COP-COVID-19
             
            NCT04358783
            RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
            20/11 inconclusive
              DAWN-Plasma
               
              NCT04429854
              RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
              320/163 inconclusive
                Holm K
                 
                NCT04600440
                RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
                17/14 inconclusive
                  Kirenga
                   
                  NCT04542941
                  RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
                  67/69 inconclusive
                    Menichetti
                     
                    NCT04716556
                    RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
                    241/246 inconclusive
                    • inconclusive 12 % decrease in death or ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
                    NCT04385199
                     
                    NCT04385199
                    RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedlow
                    20/10 inconclusive
                      NCT04397757
                       
                      NCT04397757
                      RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
                      41/39 suggested
                      • suggested 85 % decrease in deaths,death D28 with a moderate degree of certainty due to some concern in risk of bias
                      NCT04403477 (two doses)
                       
                      NCT04403477
                      RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedlow
                      40/20 inconclusive
                        NCT04442191
                         
                        NCT04442191
                        RCTconvalescent plasma treatmentplaceboCOVID 19 hospitalizedlow
                        8/6 inconclusive
                          NCT04528368
                           
                          NCT04528368
                          RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedlow
                          9/8 inconclusive
                            PC/COVID-19
                             
                            NCT04366245
                            RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedlow
                            38/36 inconclusive
                              PERUCONPLASMA
                               
                              NCT04497324
                              RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedlow
                              12/13 inconclusive
                                RECOVERY (plasma)
                                 
                                NCT04381936
                                RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
                                5795/5763 inconclusive
                                • inconclusive 0 % increase in deaths,death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
                                ConCOVID (Gharbharan et al.)
                                 
                                NCT04342182
                                RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
                                43/43 inconclusive
                                • inconclusive 5 % decrease in deaths (PE) with a moderate degree of certainty due to some concern in risk of bias
                                CONFIDENT
                                 
                                NCT04558476
                                RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedlow
                                150/151 inconclusive
                                  ConPlas-19
                                   
                                  NCT04345523
                                  RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
                                  179/171 inconclusive
                                  • inconclusive 6 % decrease in death or ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
                                  COPLA-II trial
                                   
                                  NCT04425915
                                  RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
                                  200/200 suggested
                                  • suggested 42 % decrease in mechanical ventilation with a moderate degree of certainty due to some concern in risk of bias
                                  Sakoulas
                                   
                                  NCT04411667
                                  RCTimmunoglobulin therapy standard of careCOVID 19 hospitalizedsome concern
                                  17/17 inconclusive
                                  • inconclusive 81 % decrease in mechanical ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
                                  Salman
                                   
                                  NCT04530370
                                  RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
                                  15/15 inconclusive

                                    COVID 19 all comers meta-analysis

                                    LIFESAVER
                                     
                                    NCT04374526
                                    RCTconvalescent plasma treatmentstandard of careCOVID 19 all comerslow
                                    4/8 inconclusive

                                      COVID-19 mild to moderate meta-analysis

                                      Libster
                                       
                                      NCT04479163
                                      RCTconvalescent plasma treatmentplaceboCOVID-19 mild to moderatelow
                                      80/80 conclusif
                                      • demonstrated 48 % decrease in clinical deterioration (PE) with a high degree of certainty due to low risk of bias

                                      COVID-19 severe or critically meta-analysis

                                      CAPSID
                                       
                                      NCT04433910
                                      RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallysome concern
                                      53/52 inconclusive
                                      • inconclusive 58 % increase in clinical improvement (PE) with a moderate degree of certainty due to some concern in risk of bias
                                      CP-COVID-19
                                       
                                      NCT04332835
                                      RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallysome concern
                                      49/51 inconclusive
                                      • inconclusive 12 % increase in viral clearance (PE) with a moderate degree of certainty due to some concern in risk of bias
                                      O’Donnell
                                       
                                      NCT04359810
                                      RCTconvalescent plasma treatmentplaceboCOVID-19 severe or criticallylow
                                      150/73 inconclusive
                                      • inconclusive 38 % increase in clinical improvement (28-day) (PE) with a high degree of certainty due to low risk of bias
                                      Pouladzadeh
                                       
                                      IRCT20200310046736N1
                                      RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallysome concern
                                      31/31 suggested
                                      • suggested 6.3-fold increase in clinical improvement,clinical improvement (28-day) with a moderate degree of certainty due to some concern in risk of bias
                                      Raman
                                       
                                      CTRI/2020/06/026222
                                      RCTimmunoglobulin therapy standard of careCOVID-19 severe or criticallysome concern
                                      50/50 suggested
                                      • suggested 35.4-fold increase in viral clearance ,viral clearance by day 14 with a moderate degree of certainty due to some concern in risk of bias
                                      RECOVER
                                       
                                      EudCT 2020-001632-10
                                      RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallylow
                                      43/47 inconclusive
                                        REMAP-CAP (plasma)
                                         
                                        NCT02735707
                                        RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallylow
                                        1095/916 safety concern
                                        • statistically significant 1.3-fold increase in serious adverse events with a high degree of certainty due to low risk of bias
                                        Sekine (PLACOVID)
                                         
                                        NCT04547660
                                        RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallysome concern
                                        80/80 inconclusive
                                        • inconclusive 6 % decrease in clinical improvement,clinical improvement (28-day) (PE) with a moderate degree of certainty due to some concern in risk of bias
                                        AlQahtani
                                         
                                        NCT04356534
                                        RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallysome concern
                                        20/20 inconclusive
                                        • inconclusive 33 % decrease in mechanical ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
                                        Li
                                         
                                        ChiCTR2000029757
                                        RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallysome concern
                                        52/51 inconclusive
                                        • inconclusive 40 % increase in clinical improvement,clinical improvement (time to event analysis only) (PE) with a moderate degree of certainty due to some concern in risk of bias
                                        PlasmAr
                                         
                                        NCT04344535
                                        RCTconvalescent plasma treatmentplaceboCOVID-19 severe or criticallylow
                                        228/106 inconclusive
                                        • inconclusive 19 % decrease in clinical improvement (PE) with a high degree of certainty due to low risk of bias
                                        Rasheed RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallysome concern
                                        21/28 inconclusive
                                          Tabarsi
                                           
                                          IRCT20151227025726N2
                                          RCTimmunoglobulin therapy standard of careCOVID-19 severe or criticallysome concern
                                          52/32 inconclusive
                                          • inconclusive 10 % increase in deaths,death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
                                          • inconclusive 49 % increase in mechanical ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
                                          • inconclusive 44 % decrease in ICU admission (PE) with a moderate degree of certainty due to some concern in risk of bias
                                          12 studies excluded by filtering options (7 RCT / 5 OBS)

                                          PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
                                          Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).