Study explorer (study characteristics and results) method abbreviations pdf   xlsx

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Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 outpatients meta-analysis

COLCORONA, 2021
 
NCT04322682
RCTcolchicineplaceboCOVID 19 outpatientslow
2235/2253 safety concern
  • inconclusive 21 % decrease in hospitalization or death (PE) with a high degree of certainty due to low risk of bias
  • statistically significant 74 % increase in related AE (TRAE) with a high degree of certainty due to low risk of bias
PRINCIPLE (COLCHICINE), 2021
 
ISRCTN86534580
RCTcolchicinestandard of careCOVID 19 outpatientssome concern
212/2081 inconclusive
  • inconclusive 29 % increase in hospitalization or death (PE) with a moderate degree of certainty due to some concern in risk of bias
  • inconclusive 8 % decrease in recovery (PE) with a moderate degree of certainty due to some concern in risk of bias

PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).