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Study Ref. studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 hospitalized meta-analysis

RECOVERY colchicine, 2021
 
NCT04381936
RCTcolchicinestandard of careCOVID 19 hospitalizedNA
-/- inconclusive
  • inconclusive 2 % increase in deaths (PE)
GRECCO-19, 2020
 
NCT04326790
RCTcolchicinestandard of careCOVID 19 hospitalizedsome concern
55/50 suggested
  • suggested 89 % decrease in clinical deterioration (PE) with a moderate degree of certainty due to some concern in risk of bias
Lopes MIF, 2020
 
RBR-8jyhxh
RCTcolchicineplaceboCOVID 19 hospitalizedhigh
19/19 inconclusive
    Salehzadeh, 2020
     
    IRCT20200418047126N1
    RCTcolchicineplaceboCOVID 19 hospitalizedsome concern
    50/50 inconclusive
      Comparing two groups showed significantly different only in the duration of hospitalized (P<0.05). Although in colchicine group dyspnea was improved more rapid than the placebo group, but it was not meaningful.

      PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
      Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).