Study explorer (study characteristics and results) method abbreviations pdf   xlsx

display ongoing studies
Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID-19 mild to moderate meta-analysis

Coalition Covid-19 Brazil I (Cavalcanti) - HCQ AZI
 
NCT04322123
RCTazithromycin plus hydroxychloroquinestandard of careCOVID-19 mild to moderatesome concern
217/227 safety concern
  • inconclusive 1 % decrease in clinical deterioration (PE) with a moderate degree of certainty due to some concern in risk of bias
  • statistically significant 1.2-fold increase in adverse events with a moderate degree of certainty due to some concern in risk of bias
  • statistically significant 2.5-fold increase in elevated liver enzymes with a moderate degree of certainty due to some concern in risk of bias
  • statistically significant 8.8-fold increase in long QT with a moderate degree of certainty due to some concern in risk of bias

PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).