Study explorer (study characteristics and results) method abbreviations pdf   xlsx

display ongoing studies
Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 hospitalized meta-analysis

RECOVERY (Aspirin)
 
NCT04381936
RCTAspirinstandard of careCOVID 19 hospitalizedsome concern
7351/7541 suggested
  • inconclusive 4 % decrease in deaths,deaths (time to event analysis only),death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 6 % increase in hospital discharge with a moderate degree of certainty due to some concern in risk of bias

COVID 19 all comers meta-analysis

Gunst JD
 
NCT04321096
RCTcamostat mesilateplaceboCOVID 19 all comerssome concern
139/69 inconclusive

    COVID-19 mild to moderate meta-analysis

    VERU-111
     
    NCT04842747
    RCTsabizabulinplaceboCOVID-19 mild to moderatesome concern
    134/70 conclusif
    • demonstrated 70 % decrease in 14-days deaths (PE) with a moderate degree of certainty due to some concern in risk of bias
    Crippa (CANDIDATE)
     
    NCT04467918
    RCTCannabidiolplaceboCOVID-19 mild to moderatesome concern
    53/52 inconclusive

      COVID-19 severe or critically meta-analysis

      Fragoso-Saavedra (PISCO)
       
      NCT04343963
      RCTpyridostigmineplaceboCOVID-19 severe or criticallysome concern
      94/94 suggested
      • suggested 68 % decrease in death D28 with a moderate degree of certainty due to some concern in risk of bias
      • suggested 67 % decrease in deaths,deaths (time to event analysis only) with a moderate degree of certainty due to some concern in risk of bias
      • suggested 54 % decrease in death or ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
      1 study excluded by filtering options (1 RCT / 0 OBS)

      PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
      Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).