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COVID 19 hospitalized meta-analysis

RECOVERY (plasma), 2021
  NCT04381936		 RCTconvalescent plasma treatmentcontrolCOVID 19 hospitalizedNA
-/- inconclusive
    Balcells, 2020
          NCT04375098    		 RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedlow
    		28/30 inconclusive
    • inconclusive 33 % decrease in death or ventilation (PE) with a high degree of certainty due to low risk of bias
    ConPlas-19, 2020
          NCT04345523    		 RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
    		38/43 inconclusive
      Gharbharan et al., 2020
              NCT04342182      		 RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
      		43/43 inconclusive
      • inconclusive 5 % decrease in deaths (PE) with a moderate degree of certainty due to some concern in risk of bias
      Abolghasemi, 2020
              IRCT20200325046860N1      		 OBSconvalescent plasma treatmentcontrolCOVID 19 hospitalizedcritical
      		115/74 inconclusive

        COVID-19 mild to moderate meta-analysis

        Libster, 2020
                  NCT04479163        		 RCTconvalescent plasma treatmentplaceboCOVID-19 mild to moderatelow
        		80/80 conclusif
        • demonstrated 48 % decrease in clinical deterioration (PE) with a high degree of certainty due to low risk of bias
        PLACID, 2020
                  CTRI/2020/04/024775        		 RCTconvalescent plasma treatmentstandard of careCOVID-19 mild to moderatehigh
        		235/229 suggested
        • inconclusive 7 % increase in death or transfer to ICU (PE) but with a low degree of certainty due to high risk of bias
        • suggested 20 % increase in PCR-negative conversion (7-day) but with a low degree of certainty due to high risk of bias

        COVID-19 severe or critically meta-analysis

        AlQahtani, 2020
                  NCT04356534        		 RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallysome concern
        		20/20 inconclusive
        • inconclusive 33 % decrease in ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
        Bajpai M, 2020
                  NCT04346446        		 RCTconvalescent plasma treatmentcontrolCOVID-19 severe or criticallyhigh
        		14/15 inconclusive
        • inconclusive 74 % decrease in off oxygenation (PE) but with a low degree of certainty due to high risk of bias
        PlasmAr, 2020
                  NCT04344535        		 RCTconvalescent plasma treatmentcontrolCOVID-19 severe or criticallylow
        		228/105 inconclusive
        • inconclusive 19 % decrease in clinical improvement (PE) with a high degree of certainty due to low risk of bias
        PlasmAr, 2020
                  NCT04344535        		 RCTconvalescent plasma treatmentplaceboCOVID-19 severe or criticallylow
        		228/105 inconclusive
        • inconclusive 19 % decrease in clinical improvement (PE) with a high degree of certainty due to low risk of bias
        Li, 2015
                  ChiCTR2000029757        		 RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallysome concern
        		52/51 inconclusive
        • inconclusive 40 % increase in clinical improvement (PE) with a moderate degree of certainty due to some concern in risk of bias
        Duan, 2020 OBSconvalescent plasma treatmentcontrolCOVID-19 severe or criticallycritical
        		10/10 inconclusive
          Hegerova, 2020 OBSconvalescent plasma treatmentcontrolCOVID-19 severe or criticallycritical
          		20/20 inconclusive
            Rasheed, 2020 OBSconvalescent plasma treatmentcontrolCOVID-19 severe or criticallycritical
            		21/28 inconclusive
              Sean, 2020 OBSconvalescent plasma treatmentcontrolCOVID-19 severe or criticallycritical
              		39/156 inconclusive

                PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
                Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

                 

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