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COVID 19 hospitalized meta-analysis

RECOVERY dexamethasone, 2020
  NCT04381936		 RCTdexamethasonestandard of careCOVID 19 hospitalizedsome concern
2104/4321 conclusif
  • demonstrated 17 % decrease in deaths (PE) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 10 % increase in hospital discharge with a moderate degree of certainty due to some concern in risk of bias
in an exploratory subgroup analysis there was no benefit among patients who did not require oxygen (1.22 [0.86 to 1.75]; p=0.14)
Fernández Cruz, 2020 OBScorticosteroidsstandard of careCOVID 19 hospitalizedserious
396/67 suggested
  • suggested 66 % decrease in deaths but with a low degree of certainty due to high risk of bias

COVID-19 severe or critically meta-analysis

CODEX (Tomazini), 2020
  NCT04327401		 RCTdexamethasonestandard of careCOVID-19 severe or criticallysome concern
151/148 inconclusive
    Edalatifard, 2020
          IRCT20200404046947N1    		 RCTmethylprednisolonestandard of careCOVID-19 severe or criticallyhigh
    		34/34 conclusif
    • demonstrated 71 % decrease in deaths (PE) but with a low degree of certainty due to high risk of bias
    REMAP-CAP, fixed 7-day course, 2020
          NCT02735707    		 RCTHydrocortisonestandard of careCOVID-19 severe or criticallysome concern
    		143/108 inconclusive
      REMAP-CAP, shock-dependent course, 2020
              NCT02735707      		 RCTcorticosteroidsstandard of careCOVID-19 severe or criticallysome concern
      		152/108 inconclusive
        Jianfeng, 2020 OBScorticosteroidsstandard of careCOVID-19 severe or criticallyserious
        		-/- safety concern
        • statistically significant 1.8-fold increase in deaths,deaths (time to event analysis only) but with a low degree of certainty due to high risk of bias
        • statistically significant 2.0-fold increase in deaths,deaths (time to event analysis only) but with a low degree of certainty due to high risk of bias
        Raef, 2020 OBScorticosteroidsstandard of careCOVID-19 severe or criticallycritical
        		-/- suggested
        • suggested 55 % decrease in deaths but with a very low degree of certainty due to critical risk of bias

        PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
        Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

         

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