Study explorer (study characteristics and results) method abbreviations pdf   xlsx

display ongoing studies
Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 hospitalized meta-analysis

RECOVERY dexamethasone
  NCT04381936		 RCTdexamethasonestandard of careCOVID 19 hospitalizedsome concern
2104/4321 conclusif
  • demonstrated 17 % decrease in deaths (PE) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 10 % increase in hospital discharge with a moderate degree of certainty due to some concern in risk of bias
  • suggested 23 % decrease in mechanical ventilation with a moderate degree of certainty due to some concern in risk of bias
in an exploratory subgroup analysis there was no benefit among patients who did not require oxygen (1.22 [0.86 to 1.75]; p=0.14)

COVID-19 severe or critically meta-analysis

Jamaati
  IRCT20151227025726N1		 RCTdexamethasonestandard of careCOVID-19 severe or criticallysome concern
25/25 suggested
  • inconclusive 19 % increase in deaths,death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
  • inconclusive 38 % increase in mechanical ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 3.9-fold increase in radiologic improvement (14-day) with a moderate degree of certainty due to some concern in risk of bias
CODEX (Tomazini)
  NCT04327401		 RCTdexamethasonestandard of careCOVID-19 severe or criticallysome concern
151/148 inconclusive
    DEXA-COVID19
          NCT04325061    		 RCTdexamethasonestandard of careCOVID-19 severe or criticallylow
    		7/12 inconclusive
      Steroids-SARI
              NCT04244591      		 RCTmethylprednisolonestandard of careCOVID-19 severe or criticallysome concern
      		24/23 inconclusive
        7 studies excluded by filtering options (4 RCT / 3 OBS)

        PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
        Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

         

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