Study explorer (study characteristics and results) method abbreviations pdf   xlsx

display ongoing studies
Study Ref. studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 hospitalized meta-analysis

GLUCOCOVID, 2020 RCTcorticosteroidscontrolCOVID 19 hospitalizedhigh
34/29 suggested
  • suggested 45 % decrease in clinical deterioration but with a low degree of certainty due to high risk of bias
Metcovid, 2020
 
NCT04343729
RCTmethylprednisoloneplaceboCOVID 19 hospitalizedsome concern
209/207 inconclusive
  • inconclusive 8 % decrease in deaths (PE) with a moderate degree of certainty due to some concern in risk of bias
RECOVERY dexamethasone, 2020
 
NCT04381936
RCTdexamethasonestandard of careCOVID 19 hospitalizedsome concern
2104/4321 conclusif
  • demonstrated 17 % decrease in deaths (PE) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 10 % increase in hospital discharge with a moderate degree of certainty due to some concern in risk of bias
in an exploratory subgroup analysis there was no benefit among patients who did not require oxygen (1.22 [0.86 to 1.75]; p=0.14)
Fernández Cruz, 2020 OBScorticosteroidsstandard of careCOVID 19 hospitalizedserious
396/67 suggested
  • suggested 66 % decrease in deaths but with a low degree of certainty due to high risk of bias

COVID-19 severe or critically meta-analysis

CAPE-COVID, 2020
 
NCT02517489
RCTHydrocortisoneplaceboCOVID-19 severe or criticallylow
76/73 inconclusive
  • inconclusive 29 % decrease in death or ventilation (PE) with a high degree of certainty due to low risk of bias
CODEX (Tomazini), 2020
 
NCT04327401
RCTdexamethasonestandard of careCOVID-19 severe or criticallysome concern
151/148 inconclusive
    Edalatifard, 2020
     
    IRCT20200404046947N1
    RCTmethylprednisolonestandard of careCOVID-19 severe or criticallyhigh
    34/34 conclusif
    • demonstrated 71 % decrease in deaths (PE) but with a low degree of certainty due to high risk of bias
    REMAP-CAP, fixed 7-day course, 2020
     
    NCT02735707
    RCTHydrocortisonestandard of careCOVID-19 severe or criticallysome concern
    143/108 inconclusive
      REMAP-CAP, shock-dependent course, 2020
       
      NCT02735707
      RCTcorticosteroidsstandard of careCOVID-19 severe or criticallysome concern
      152/108 inconclusive
        Jianfeng, 2020 OBScorticosteroidsstandard of careCOVID-19 severe or criticallyserious
        -/- safety concern
        • statistically significant 1.8-fold increase in deaths,deaths (time to event analysis only) but with a low degree of certainty due to high risk of bias
        • statistically significant 2.0-fold increase in deaths,deaths (time to event analysis only) but with a low degree of certainty due to high risk of bias
        Raef, 2020 OBScorticosteroidsstandard of careCOVID-19 severe or criticallycritical
        -/- suggested
        • suggested 55 % decrease in deaths but with a very low degree of certainty due to critical risk of bias
        Lu, 2020 OBScorticosteroidscontrolCOVID-19 severe or criticallyserious
        151/93 inconclusive

          PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
          Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).