Study explorer (study characteristics and results) method abbreviations pdf   xlsx

display ongoing studies
Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 hospitalized meta-analysis

Metcovid
 
NCT04343729
RCTmethylprednisoloneplaceboCOVID 19 hospitalizedsome concern
209/207 inconclusive
  • inconclusive 8 % decrease in deaths,death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
RECOVERY dexamethasone
 
NCT04381936
RCTdexamethasonestandard of careCOVID 19 hospitalizedsome concern
2104/4321 conclusif
  • demonstrated 17 % decrease in deaths (PE) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 10 % increase in hospital discharge with a moderate degree of certainty due to some concern in risk of bias
  • suggested 23 % decrease in mechanical ventilation with a moderate degree of certainty due to some concern in risk of bias
in an exploratory subgroup analysis there was no benefit among patients who did not require oxygen (1.22 [0.86 to 1.75]; p=0.14)
Tang X
 
NCT04273321
RCTmethylprednisoloneplaceboCOVID 19 hospitalizedsome concern
43/43 suggested
  • inconclusive 0 % increase in clinical deterioration (PE) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 78 % increase in viral clearance ,viral clearance (time to event analysis only) with a moderate degree of certainty due to some concern in risk of bias

COVID-19 severe or critically meta-analysis

Jamaati
 
IRCT20151227025726N1
RCTdexamethasonestandard of careCOVID-19 severe or criticallysome concern
25/25 suggested
  • inconclusive 19 % increase in deaths,death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
  • inconclusive 38 % increase in mechanical ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 3.9-fold increase in radiologic improvement (14-day) with a moderate degree of certainty due to some concern in risk of bias
Munch (COVID-STEROID)
 
NCT04348305
RCTHydrocortisoneplaceboCOVID-19 severe or criticallylow
16/14 no results
    CAPE-COVID
     
    NCT02517489
    RCTHydrocortisoneplaceboCOVID-19 severe or criticallylow
    76/73 inconclusive
    • inconclusive 29 % decrease in death or ventilation (PE) with a high degree of certainty due to low risk of bias
    CODEX (Tomazini)
     
    NCT04327401
    RCTdexamethasonestandard of careCOVID-19 severe or criticallysome concern
    151/148 inconclusive
      DEXA-COVID19
       
      NCT04325061
      RCTdexamethasonestandard of careCOVID-19 severe or criticallylow
      7/12 inconclusive
        Steroids-SARI
         
        NCT04244591
        RCTmethylprednisolonestandard of careCOVID-19 severe or criticallysome concern
        24/23 inconclusive
          9 studies excluded by filtering options (5 RCT / 4 OBS)

          PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
          Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).