Study explorer (study characteristics and results) method abbreviations pdf   xlsx

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Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 outpatients meta-analysis

COPE – Coalition V
 
NCT04466540
RCThydroxychloroquineplaceboCOVID 19 outpatientssome concern
689/683 inconclusive
  • inconclusive 23 % decrease in hospitalization (PE) with a moderate degree of certainty due to some concern in risk of bias
COVID-PEP Severity (Skipper)
 
NCT04308668
RCThydroxychloroquineplaceboCOVID 19 outpatientssome concern
244/247 safety concern
  • statistically significant 1.8-fold increase in adverse events with a moderate degree of certainty due to some concern in risk of bias
change in symptom severity over 14 days did not differ between the hydroxychloroquine and placebo groups (difference in symptom severity: relative, 12%; absolute, −0.27 points [95% CI, −0.61 to 0.07 points]; P = 0.117)
1 study excluded by filtering options (1 RCT / 0 OBS)

PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).