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Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID-19 prophylaxis (excluding childrens) meta-analysis

Rojas-Serrano, 2021
 
NCT04318015
RCThydroxychloroquineplaceboCOVID-19 prophylaxis (excluding childrens)some concern
65/65 inconclusive
  • inconclusive 82 % decrease in symptomatic Covid-19 (PE) with a moderate degree of certainty due to some concern in risk of bias
Barnabas RV, 2020
 
NCT04328961
RCThydroxychloroquineplaceboCOVID-19 prophylaxis (excluding childrens)low
407/422 safety concern
  • inconclusive 10 % increase in conversion to SARS-CoV- 2–positive status via NP swab (PE) with a high degree of certainty due to low risk of bias
  • statistically significant 58 % increase in adverse events with a high degree of certainty due to low risk of bias
BCN PEP-CoV-2-Study 1 (Mitja NEJM), 2020
 
NCT04304053
RCThydroxychloroquinestandard of careCOVID-19 prophylaxis (excluding childrens)some concern
1116/1198 safety concern
  • inconclusive 14 % decrease in conversion to SARS-CoV- 2–positive status via NP swab (PE) with a moderate degree of certainty due to some concern in risk of bias
  • statistically significant 19.3-fold increase in adverse events with a moderate degree of certainty due to some concern in risk of bias
COVID PREP (HCQ 1x week, Rajasingham), 2020
 
NCT04328467
RCThydroxychloroquineplaceboCOVID-19 prophylaxis (excluding childrens)low
494/494 suggested
    COVID PREP HCQ (2x week, Rajasingham), 2020
     
    NCT04328467
    RCThydroxychloroquineplaceboCOVID-19 prophylaxis (excluding childrens)low
    495/494 safety concern
    • inconclusive 26 % decrease in new illness compatible with Covid-19 (PE) with a high degree of certainty due to low risk of bias
    • statistically significant 1.0-fold increase in adverse events with a high degree of certainty due to low risk of bias
    COVID-PEP-Post exposure (Boulware), 2020
     
    NCT04308668
    RCThydroxychloroquineplaceboCOVID-19 prophylaxis (excluding childrens)low
    414/407 safety concern
    • statistically significant 2.3-fold increase in adverse events with a high degree of certainty due to low risk of bias
    Grau-Pujol, 2020
     
    NCT04331834
    RCThydroxychloroquineplaceboCOVID-19 prophylaxis (excluding childrens)some concern
    142/127 inconclusive
      PATCH-cohort 3 PreP (Abella), 2020
       
      NCT04329923
      RCThydroxychloroquineplaceboCOVID-19 prophylaxis (excluding childrens)some concern
      66/66 inconclusive
      • inconclusive 5 % decrease in symptomatic Covid-19,conversion to SARS-CoV- 2–positive status via NP swab (PE) with a moderate degree of certainty due to some concern in risk of bias
      3 studies excluded by filtering options (1 RCT / 2 OBS)

      PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
      Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).