Study explorer (study characteristics and results) method abbreviations pdf   xlsx

display ongoing studies
Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 hospitalized meta-analysis

Abd-Elsalam, 2020
 
NCT04353336
RCThydroxychloroquinestandard of careCOVID 19 hospitalizedsome concern
97/97 inconclusive
    Chen, 2020
     
    NCT04384380
    RCThydroxychloroquinestandard of careCOVID 19 hospitalizedsome concern
    21/12 inconclusive
      Gonzalez_HCQ, 2020
       
      NCT04391127
      RCThydroxychloroquineplaceboCOVID 19 hospitalizedsome concern
      33/37 inconclusive
        HAHPS, 2020
         
        NCT04329832
        RCThydroxychloroquineazithromycinCOVID 19 hospitalizedsome concern
        42/43 inconclusive
        • inconclusive 7 % increase in clinical deterioration (PE) with a moderate degree of certainty due to some concern in risk of bias
        Huang, 2020
         
        ChiCTR2000029542
        RCTchloroquinelopinavir/ritonavirCOVID 19 hospitalizedsome concern
        10/12 suggested
        • suggested 100 % increase in hospital discharge with a moderate degree of certainty due to some concern in risk of bias
        HYCOVID, 2020
         
        NCT04325893
        RCThydroxychloroquineplaceboCOVID 19 hospitalizedsome concern
        124/123 inconclusive
        • inconclusive 12 % increase in death or ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
        NO COVID-19 (Lyngbakken), 2020
         
        NCT04316377
        RCThydroxychloroquinestandard of careCOVID 19 hospitalizedsome concern
        27/26 inconclusive
          ORCHID, 2020
           
          NCT04332991
          RCThydroxychloroquineplaceboCOVID 19 hospitalizedlow
          242/237 inconclusive
          • inconclusive 2 % increase in clinical improvement,clinical improvement (14-day) (PE) with a high degree of certainty due to low risk of bias
          RECOVERY, 2020
           
          NCT04381936
          RCThydroxychloroquinestandard of careCOVID 19 hospitalizedsome concern
          1561/3155 safety concern
          • inconclusive 9 % increase in deaths,deaths (time to event analysis only),death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
          • statistically significant 14 % increase in death or ventilation with a moderate degree of certainty due to some concern in risk of bias
          SOLIDARITY (WHO study) HCQ, 2020
           
          NCT04315948
          RCThydroxychloroquinestandard of careCOVID 19 hospitalizedsome concern
          947/906 inconclusive
          • inconclusive 19 % increase in deaths,deaths (time to event analysis only),death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
          TEACH, 2020
           
          NCT04369742
          RCThydroxychloroquineplaceboCOVID 19 hospitalizedsome concern
          67/61 inconclusive
          • inconclusive 80 % increase in clinical deterioration (PE) with a moderate degree of certainty due to some concern in risk of bias
          • inconclusive 16 % increase in adverse events (PE) with a moderate degree of certainty due to some concern in risk of bias

          COVID-19 mild to moderate meta-analysis

          Coalition Covid-19 Brazil I (Cavalcanti)-Hydroxychloroquine, 2020
           
          NCT04322123
          RCThydroxychloroquinestandard of careCOVID-19 mild to moderatesome concern
          221/227 safety concern
          • statistically significant 74 % increase in adverse events with a moderate degree of certainty due to some concern in risk of bias
          HC-nCoV (Shanghai), 2020
           
          NCT04261517
          RCThydroxychloroquinestandard of careCOVID-19 mild to moderatesome concern
          15/15 inconclusive

            COVID-19 severe or critically meta-analysis

            HYDRA (Hernandez-Cardenas), 2021
             
            NCT04315896
            RCThydroxychloroquineplaceboCOVID-19 severe or criticallysome concern
            106/108 inconclusive
            • inconclusive 20 % decrease in deaths,deaths (time to event analysis only),death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
            31 studies excluded by filtering options (16 RCT / 15 OBS)

            PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
            Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).