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COVID-19 prophylaxis meta-analysis

Abella, 2020
  NCT04329923		 hydroxychloroquineplaceboCOVID-19 prophylaxisNA
65/65 safety concern
  • inconclusive 6 % increase in conversion to SARS-CoV- 2–positive status via NP swab (PE)
  • statistically significant 1.3-fold increase in conversion to SARS-CoV- 2–positive status via NP swab
Barnabas RV, 2020
  NCT04328961		 RCThydroxychloroquineplaceboCOVID-19 prophylaxislow
407/422 safety concern
  • inconclusive 10 % increase in conversion to SARS-CoV- 2–positive status via NP swab (PE) with a high degree of certainty due to low risk of bias
  • statistically significant 58 % increase in adverse events with a high degree of certainty due to low risk of bias
BCN PEP-CoV-2-Study 1 (Mitja NEJM), 2020
  NCT04304053		 RCThydroxychloroquinestandard of careCOVID-19 prophylaxissome concern
1116/1198 safety concern
  • inconclusive 14 % decrease in new illness compatible with Covid-19 ,laboratory-confirmed Covid-19 (PE) with a moderate degree of certainty due to some concern in risk of bias
  • statistically significant 19.3-fold increase in adverse events with a moderate degree of certainty due to some concern in risk of bias
COVID PREP HCQ 1x week (Rajasingham), 2020
  NCT04328467		 RCThydroxychloroquineplaceboCOVID-19 prophylaxislow
494/494 suggested
    COVID PREP HCQ 2x week (Rajasingham), 2020
          NCT04328467    		 RCThydroxychloroquineplaceboCOVID-19 prophylaxislow
    		495/494 safety concern
    • inconclusive 26 % decrease in new illness compatible with Covid-19 (PE) with a high degree of certainty due to low risk of bias
    • statistically significant 1.0-fold increase in adverse events with a high degree of certainty due to low risk of bias
    COVID-PEP-Post exposure (Boulware), 2020
          NCT04308668    		 RCThydroxychloroquineplaceboCOVID-19 prophylaxislow
    		414/407 safety concern
    • statistically significant 2.3-fold increase in adverse events with a high degree of certainty due to low risk of bias
    Grau-Pujol, 2020
          NCT04331834    		 RCThydroxychloroquineplaceboCOVID-19 prophylaxissome concern
    		142/127 inconclusive
      PATCH-cohort 3 PreP (Abella), 2020
              NCT04329923      		 RCThydroxychloroquineplaceboCOVID-19 prophylaxissome concern
      		66/66 inconclusive
      • inconclusive 5 % decrease in laboratory-confirmed Covid-19,conversion to SARS-CoV- 2–positive status via NP swab (PE) with a moderate degree of certainty due to some concern in risk of bias
      Rentsch, 2020 OBShydroxychloroquineCOVID-19 prophylaxisNA
      		-/- ongoing
        EPI-PHARE unpublished OBSchloroquine and derivativescontrolCOVID-19 prophylaxisserious
        		-/- inconclusive

          PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
          Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

           

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