Study explorer (study characteristics and results)

display ongoing studies
Study studied treatmentcontrol treatmentpatientsrisk of biassample sizes Results

chloroquine

Chen, 2020OBSchloroquinecontrolCOVID 19 hospitalizedcritical
163/121 inconclusive no statistically significant benefit
Huang, 2020OBSchloroquinecontrolCOVID 19 hospitalizedcritical
197/176 suggested
  • suggested 5.1-fold increase in PCR-negative conversion (14-day) but with a very low degree of certainty due to critical risk of bias
  • Mehra, 2020OBSchloroquinecontrolCOVID 19 hospitalizedserious
    14888/81144 safety concern
  • safety concern with statistically significant 37 % increase in deaths,deaths (time to event analysis only)
  • safety concern with statistically significant 2.6-fold increase in arrhythmia,ventricular arrhythmia
  • chloroquine and derivatives

    Tang, 2020
     
    ChiCTR2000029868
    RCTchloroquine and derivativesstandard of careCOVID 19 hospitalizedhigh
    75/75 inconclusive no statistically significant benefit
    Peymani, 2016RCTchloroquine and derivativesplaceboinfections other than COVID-19high
    6/4 suggested
  • suggested 76.0-fold increase in clinical improvement but with a low degree of certainty due to high risk of bias
  • Borges, 2013RCTchloroquine and derivativesplaceboinfections other than COVID-19some concern
    63/66 suggested
  • suggested 29.8-fold increase in clinical improvement with a moderate degree of certainty due to some concern in risk of bias
  • Paton, 2011
     
    NCT01078779
    RCTchloroquine and derivativesplaceboinfections other than COVID-19low
    757/749 inconclusive
  • inconclusive 54 % increase in Influenza-like infection with a high degree of certainty due to low risk of bias
  • Tricou, 2010RCTchloroquine and derivativesplaceboinfections other than COVID-19low
    278/276 inconclusive no statistically significant benefit

    hydroxychloroquine

    Gautret et al., 2020NRahydroxychloroquinestandard of careCOVID 19 all comersserious
    20/16 suggested
  • suggested 15.3-fold increase in PCR-negative conversion but with a low degree of certainty due to high risk of bias
  • a viral load reduction/disappearance is claimed but the numerous methological limits preclude any strong conclusion
    Geleris, 2020OBShydroxychloroquinecontrolCOVID 19 hospitalizedserious
    811/565 inconclusive no statistically significant benefit
    HC-nCoV (Shanghai), 2020
     
    NCT04261517
    RCThydroxychloroquinestandard of careCOVID-19 mild to moderatesome concern
    15/15 inconclusive no statistically significant benefit
    Huang, 2020
     
    ChiCTR2000029542
    RCThydroxychloroquinelopinavir/ritonavirCOVID 19 hospitalizedsome concern
    10/12 inconclusive no statistically significant benefit
    Magagnoli (HC), 2020OBShydroxychloroquinecontrolCOVID 19 hospitalizedserious
    97/158 safety concern
  • safety concern with statistically significant 1.6-fold increase in deaths,deaths (time to event analysis only)
  • Mahevas, 2020OBShydroxychloroquinestandard of careCOVID-19 severe or criticallyserious
    84/97 inconclusive no statistically significant benefit
    Mehra, 2020OBShydroxychloroquinecontrolCOVID 19 hospitalizedserious
    14888/81144 safety concern
  • safety concern with statistically significant 34 % increase in deaths,deaths (time to event analysis only)
  • safety concern with statistically significant 1.4-fold increase in arrhythmia,ventricular arrhythmia
  • Novales, 2020OBShydroxychloroquinecontrolCOVID 19 hospitalizedcritical
    123/43 suggested
  • suggested 93 % decrease in deaths but with a very low degree of certainty due to critical risk of bias
  • Rosenberg, 2020OBShydroxychloroquinecontrolCOVID 19 hospitalizedserious
    -/- safety concern no statistically significant benefit
  • safety concern with 91 % increase in cardiac arrest (not statitically significant)
  • Yu, 2020OBShydroxychloroquinecontrolCOVID-19 severe or criticallycritical
    48/520 suggested
  • suggested 68 % decrease in deaths,deaths (time to event analysis only) but with a very low degree of certainty due to critical risk of bias
  • Zhaowei Chen, 2020
     
    ChiCTR2000029559
    RCThydroxychloroquinestandard of careCOVID-19 mild to moderatehigh
    31/31 suggested
  • suggested 2.4-fold increase in clinical improvement but with a low degree of certainty due to high risk of bias
  • suggested 2.4-fold increase in radiologic improvement (7-day) but with a low degree of certainty due to high risk of bias
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