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Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 hospitalized meta-analysis

COALIZAO ACTION
  NCT04394377		 RCTanticoagulant, curative dosecontrolCOVID 19 hospitalizedsome concern
311/304 inconclusive
    COALIZAO ACTION
          NCT04394377    		 RCTanticoagulant, curative doseanticoagulant, prophylactic doseCOVID 19 hospitalizedsome concern
    		311/304 inconclusive

      COVID-19 mild to moderate meta-analysis

      ATTACC, ACTIV-4a, and REMAP-CAP (noncritically ill patients)
              NCT02735707      		 RCTanticoagulant, curative dosecontrolCOVID-19 mild to moderatesome concern
      		1190/1054 conclusif
      • demonstrated 27 % increase in clinical improvement (28-day) (PE) with a moderate degree of certainty due to some concern in risk of bias
      atypical endpoints without correspondence with those of the others trials
      ATTACC, ACTIV-4a, and REMAP-CAP (noncritically ill patients)
              NCT02735707      		 RCTanticoagulant, curative doseanticoagulant, prophylactic doseCOVID-19 mild to moderatesome concern
      		1190/1054 conclusif
      • demonstrated 27 % increase in clinical improvement (28-day) (PE) with a moderate degree of certainty due to some concern in risk of bias
      atypical endpoints without correspondence with those of the others trials
      RAPID (Sholzberg)
              NCT04362085      		 RCTheparin at therapeutic dosestandard of careCOVID-19 mild to moderatesome concern
      		228/237 suggested
      • suggested 78 % decrease in deaths,death D28 with a moderate degree of certainty due to some concern in risk of bias
      • inconclusive 31 % decrease in clinical deterioration (PE) with a moderate degree of certainty due to some concern in risk of bias

      COVID-19 severe or critically meta-analysis

      COVID-PACT RCTanticoagulant, curative doseanticoagulant, prophylactic doseCOVID-19 severe or criticallysome concern
      		191/191 suggested
      • suggested 44 % decrease in Major thrombotic events or death (PE) with a moderate degree of certainty due to some concern in risk of bias
      INSPIRATION
              NCT04486508      		 RCTanticoagulation, intermediate prophylactic dosecontrolCOVID-19 severe or criticallysome concern
      		276/286 inconclusive
      • inconclusive 7 % increase in Thromboembolic events (PE) with a moderate degree of certainty due to some concern in risk of bias
      INSPIRATION
              NCT04486508      		 RCTanticoagulation, intermediate prophylactic doseanticoagulant, prophylactic doseCOVID-19 severe or criticallysome concern
      		276/286 inconclusive
      • inconclusive 7 % increase in Thromboembolic events (PE) with a moderate degree of certainty due to some concern in risk of bias
      REMAP-CAP, ACTIV-4a, ATTACC (critically ill patients)
              NCT02735707      		 RCTanticoagulant, curative dosecontrolCOVID-19 severe or criticallysome concern
      		591/616 inconclusive
      • inconclusive 17 % decrease in clinical improvement (PE) with a moderate degree of certainty due to some concern in risk of bias
      REMAP-CAP, ACTIV-4a, ATTACC (critically ill patients)
              NCT02735707      		 RCTanticoagulant, curative doseanticoagulant, prophylactic doseCOVID-19 severe or criticallysome concern
      		591/616 inconclusive
      • inconclusive 17 % decrease in clinical improvement (PE) with a moderate degree of certainty due to some concern in risk of bias
      5 studies excluded by filtering options (0 RCT / 5 OBS)

      PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
      Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

       

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