Study explorer (study characteristics and results) method abbreviations pdf   xlsx

display ongoing studies
Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 hospitalized meta-analysis

SOLIDARITY (interferon)
  NCT04315948		 RCTIFN beta-1acontrolCOVID 19 hospitalizedsome concern
2063/2064 inconclusive
  • inconclusive 16 % increase in deaths (PE) with a moderate degree of certainty due to some concern in risk of bias

COVID-19 mild to moderate meta-analysis

Fu
  ChiCTR2000030262		 RCTinterferon / TFF2standard of careCOVID-19 mild to moderatesome concern
40/40 conclusif
    Jagannathan
          NCT04331899    		 RCTpeginterferonplaceboCOVID-19 mild to moderatesome concern
    		60/60 inconclusive

      COVID-19 severe or critically meta-analysis

      Darazam (COVIFERON Interferon beta-1a)
              NCT04343768      		 RCTinterferonstandard of careCOVID-19 severe or criticallysome concern
      		20/20 suggested
      • suggested 1.4-fold increase in clinical improvement,clinical improvement (time to event analysis only) with a moderate degree of certainty due to some concern in risk of bias
      Darazam (COVIFERON Interferon beta-1b)
              NCT04343768      		 RCTIFN beta-1bstandard of careCOVID-19 severe or criticallysome concern
      		20/20 inconclusive
        Kalil (ACTT-3)
                  NCT04492475        		 RCTIFN beta-1aplaceboCOVID-19 severe or criticallysome concern
        		487/482 inconclusive
        • inconclusive 1 % decrease in clinical improvement,clinical improvement (time to event analysis only) (PE) with a moderate degree of certainty due to some concern in risk of bias
        Rahmani
                  IRCT20100228003449N2        		 RCTIFN beta-1bstandard of careCOVID-19 severe or criticallysome concern
        		40/40 conclusif
        • demonstrated 2.4-fold increase in clinical improvement (time to event analysis only) (PE) with a moderate degree of certainty due to some concern in risk of bias
        4 studies excluded by filtering options (2 RCT / 2 OBS)

        PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
        Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

         

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