favipiravir for COVID-19: living meta-analysis of clinical studies

Study explorer (study characteristics and results) method abbreviations pdf xlsx

display ongoing studies
Study	Ref.	Design	studied treatment	control treatment	patients	study risk of bias	sample sizes	Results
COVID-19 mild to moderate meta-analysis
FACCT Trial NCT04392973		RCT	favipiravir	standard of care	COVID-19 mild to moderate	some concern	125/129	inconclusive	inconclusive 15 % decrease in clinical improvement (time to event analysis only) (PE) with a moderate degree of certainty due to some concern in risk of bias
Shinkai JapicCTI-205238		RCT	favipiravir	placebo	COVID-19 mild to moderate	some concern	107/49	safety concern	inconclusive 40 % increase in clinical improvement (time to event analysis only) (PE) with a moderate degree of certainty due to some concern in risk of bias statistically significant 18.5-fold increase in adverse events with a moderate degree of certainty due to some concern in risk of bias
Solaymani-Dodaran IRCT20200318046812N1		RCT	favipiravir	lopinavir/ritonavir	COVID-19 mild to moderate	some concern	193/187	inconclusive
AVIFAVIR NCT04434248		RCT	favipiravir	standard of care	COVID 19 hospitalized, COVID-19 mild to moderate	some concern	20/20	suggested	suggested 2.9-fold increase in viral clearance ,viral clearance by day 7 (PE) with a moderate degree of certainty due to some concern in risk of bias Adverse drug reactions to AVIFAVIR were reported in 7/40 (17.5%) patients, including diarrhea, nausea, vomiting, chest pain and an increase in liver transaminase levels. The adverse drug reactions were mild to moderate and caused early discontinuation of the study drug in 2/40 (5.0%) patients.
Dabbous HM NCT04349241		RCT	favipiravir	standard of care	COVID-19 mild to moderate	some concern	50/50	inconclusive
NCT04542694 NCT04542694		RCT	favipiravir	standard of care	COVID-19 mild to moderate	some concern	100/100	suggested	suggested 1.1-fold increase in clinical improvement,clinical improvement (7-day) (PE) with a moderate degree of certainty due to some concern in risk of bias suggested 12.0-fold increase in viral clearance with a moderate degree of certainty due to some concern in risk of bias
Ruzhentsova T NCT04501783		RCT	favipiravir	standard of care	COVID-19 mild to moderate	some concern	112/56	suggested	suggested 63 % increase in clinical improvement,clinical improvement (time to event analysis only) (PE) with a moderate degree of certainty due to some concern in risk of bias inconclusive 28 % increase in viral clearance ,viral clearance (time to event analysis only) (PE) with a moderate degree of certainty due to some concern in risk of bias suggested 28 % increase in clinical improvement (14-day) with a moderate degree of certainty due to some concern in risk of bias suggested 50 % increase in clinical improvement (7-day) with a moderate degree of certainty due to some concern in risk of bias
Udwadia CTRI/2020/05/025114		RCT	favipiravir	standard of care	COVID 19 hospitalized, COVID-19 mild to moderate	some concern	75/75	safety concern	inconclusive 37 % increase in viral clearance ,viral clearance (time to event analysis only) (PE) with a moderate degree of certainty due to some concern in risk of bias suggested 75 % increase in clinical improvement,clinical improvement (time to event analysis only),clinical improvement (28-day) with a moderate degree of certainty due to some concern in risk of bias suggested 94 % decrease in mechanical ventilation (time to event analysis only),mechanical ventilation with a moderate degree of certainty due to some concern in risk of bias statistically significant 5.4-fold increase in adverse events with a moderate degree of certainty due to some concern in risk of bias
2 studies excluded by filtering options (2 RCT / 0 OBS)

PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

Study explorer (study characteristics and results) method abbreviations pdf xlsx

COVID-19 mild to moderate meta-analysis