Study explorer (study characteristics and results) method abbreviations pdf   xlsx

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Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 hospitalized meta-analysis

ASCOT
 
NCT04483960
RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedlow
15/18 inconclusive
    Co-CLARITY
     
    NCT04567173
    RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedlow
    13/12 inconclusive
      CONCOR-1
       
      NCT04348656
      RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
      625/313 safety concern
      • inconclusive 16 % increase in death or ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
      • statistically significant 27 % increase in serious adverse events with a moderate degree of certainty due to some concern in risk of bias
      COP-COVID-19
       
      NCT04358783
      RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
      20/11 inconclusive
        DAWN-Plasma
         
        NCT04429854
        RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
        320/163 inconclusive
          Holm K
           
          NCT04600440
          RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
          17/14 inconclusive
            Kirenga
             
            NCT04542941
            RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
            67/69 inconclusive
              Menichetti
               
              NCT04716556
              RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
              241/246 inconclusive
              • inconclusive 12 % decrease in death or ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
              NCT04385199
               
              NCT04385199
              RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedlow
              20/10 inconclusive
                NCT04397757
                 
                NCT04397757
                RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
                41/39 suggested
                • suggested 85 % decrease in deaths,death D28 with a moderate degree of certainty due to some concern in risk of bias
                NCT04403477 (two doses)
                 
                NCT04403477
                RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedlow
                40/20 inconclusive
                  NCT04528368
                   
                  NCT04528368
                  RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedlow
                  9/8 inconclusive
                    PC/COVID-19
                     
                    NCT04366245
                    RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedlow
                    38/36 inconclusive
                      PERUCONPLASMA
                       
                      NCT04497324
                      RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedlow
                      12/13 inconclusive
                        RECOVERY (plasma)
                         
                        NCT04381936
                        RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
                        5795/5763 inconclusive
                        • inconclusive 0 % increase in deaths,death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
                        ConCOVID (Gharbharan et al.)
                         
                        NCT04342182
                        RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
                        43/43 inconclusive
                        • inconclusive 5 % decrease in deaths (PE) with a moderate degree of certainty due to some concern in risk of bias
                        CONFIDENT
                         
                        NCT04558476
                        RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedlow
                        150/151 inconclusive
                          ConPlas-19
                           
                          NCT04345523
                          RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
                          179/171 inconclusive
                          • inconclusive 6 % decrease in death or ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
                          COPLA-II trial
                           
                          NCT04425915
                          RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
                          200/200 suggested
                          • suggested 42 % decrease in mechanical ventilation with a moderate degree of certainty due to some concern in risk of bias
                          Salman
                           
                          NCT04530370
                          RCTconvalescent plasma treatmentstandard of careCOVID 19 hospitalizedsome concern
                          15/15 inconclusive

                            COVID 19 all comers meta-analysis

                            LIFESAVER
                             
                            NCT04374526
                            RCTconvalescent plasma treatmentstandard of careCOVID 19 all comerslow
                            4/8 inconclusive

                              COVID-19 mild to moderate meta-analysis

                              PLACID
                               
                              CTRI/2020/04/024775
                              RCTconvalescent plasma treatmentstandard of careCOVID-19 mild to moderatehigh
                              235/229 suggested
                              • inconclusive 7 % increase in death or transfer to ICU (PE) but with a low degree of certainty due to high risk of bias
                              • suggested 20 % increase in viral clearance by day 7 but with a low degree of certainty due to high risk of bias

                              COVID-19 severe or critically meta-analysis

                              CAPSID
                               
                              NCT04433910
                              RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallysome concern
                              53/52 inconclusive
                              • inconclusive 58 % increase in clinical improvement (PE) with a moderate degree of certainty due to some concern in risk of bias
                              CP-COVID-19
                               
                              NCT04332835
                              RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallysome concern
                              49/51 inconclusive
                              • inconclusive 12 % increase in viral clearance (PE) with a moderate degree of certainty due to some concern in risk of bias
                              Pouladzadeh
                               
                              IRCT20200310046736N1
                              RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallysome concern
                              31/31 suggested
                              • suggested 6.3-fold increase in clinical improvement,clinical improvement (28-day) with a moderate degree of certainty due to some concern in risk of bias
                              RECOVER
                               
                              EudCT 2020-001632-10
                              RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallylow
                              43/47 inconclusive
                                REMAP-CAP (plasma)
                                 
                                NCT02735707
                                RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallylow
                                1095/916 safety concern
                                • statistically significant 1.3-fold increase in serious adverse events with a high degree of certainty due to low risk of bias
                                Sekine (PLACOVID)
                                 
                                NCT04547660
                                RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallysome concern
                                80/80 inconclusive
                                • inconclusive 6 % decrease in clinical improvement,clinical improvement (28-day) (PE) with a moderate degree of certainty due to some concern in risk of bias
                                AlQahtani
                                 
                                NCT04356534
                                RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallysome concern
                                20/20 inconclusive
                                • inconclusive 33 % decrease in mechanical ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
                                Li
                                 
                                ChiCTR2000029757
                                RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallysome concern
                                52/51 inconclusive
                                • inconclusive 40 % increase in clinical improvement,clinical improvement (time to event analysis only) (PE) with a moderate degree of certainty due to some concern in risk of bias
                                PICP19 (Ray)
                                 
                                CTRI/2020/05/025209
                                RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or critically
                                bias due to deviations from intended interventions some concern
                                bias due to missing outcome data low
                                bias in measurement of the primary outcome low
                                bias in selection of the reported result high
                                " >high
                                40/40 inconclusive Rasheed RCTconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallysome concern
                                21/28 inconclusive Bihariesingh-Sanchit (SuriCovid)
                                 
                                ISRCTN18304314 NRaconvalescent plasma treatmentstandard of careCOVID-19 severe or criticallyNA
                                28/50 uncontrolled

                                PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
                                Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).