Study explorer (study characteristics and results) method abbreviations pdf   xlsx

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Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 all comers meta-analysis

RECOVERY
  NCT04381936		 RCTbaricitinibstandard of careCOVID 19 all comerssome concern
4148/4008 conclusif
  • demonstrated 13 % decrease in deaths,death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 10 % decrease in death or ventilation with a moderate degree of certainty due to some concern in risk of bias

COVID-19 mild to moderate meta-analysis

Murugesan RCTtofacitinibstandard of careCOVID-19 mild to moderateNA
50/50 inconclusive
    Rodriguez-Garcia
          EUPAS34966    		 OBSbaricitinibstandard of careCOVID-19 mild to moderateNA
    		62/50 no results
      Cantini OBSbaricitinibstandard of careCOVID-19 mild to moderatecritical
      		113/78 suggested
      • suggested 22.9-fold increase in hospital discharge but with a very low degree of certainty due to critical risk of bias

      COVID-19 severe or critically meta-analysis

      Tziolos OBSbaricitinibstandard of careCOVID-19 severe or criticallyNA
      		193/176 suggested
      • suggested 7 % decrease in death or transfer to ICU (PE)
      • suggested 53 % decrease in deaths
      When we analyzed mortality separately, older age, lower PaO2/FiO2 ratio, and the use of HFNC but not remdesivir orbaricitinib were associated with reduced mortality. Baricitinib was not associated with shorter time to improvement

      PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
      Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

       

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