Study explorer (study characteristics and results) method abbreviations pdf   xlsx

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Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 hospitalized meta-analysis

Entrenas (Pilot Calcifediol)
  NCT04366908		 RCTVitamin Dstandard of careCOVID 19 hospitalizedsome concern
50/26 conclusif
  • inconclusive 88 % decrease in deaths (PE) with a moderate degree of certainty due to some concern in risk of bias
  • demonstrated 97 % decrease in ICU admission (PE) with a moderate degree of certainty due to some concern in risk of bias
Murai
  NCT04449718		 RCTVitamin DplaceboCOVID 19 hospitalizedsome concern
120/120 inconclusive
  • inconclusive 1 % decrease in hospital discharge (PE) with a moderate degree of certainty due to some concern in risk of bias
Annweiler (GERIA-COVID; regular intake of bolus vitamin D) OBSVitamin DcontrolCOVID 19 hospitalizedNA
29/32 suggested
  • suggested 93 % decrease in deaths (PE)
  • suggested 92 % decrease in death or ventilation
Annweiler (GERIA-COVID; Vitamin D Supplementation After COVID-19 Diagnosis) OBSVitamin DcontrolCOVID 19 hospitalizedNA
16/32 inconclusive

    COVID-19 mild to moderate meta-analysis

    Rastogi
          NCT04459247    		 RCTVitamin DplaceboCOVID-19 mild to moderateNA
    		16/24 suggested
    • suggested 5.3-fold increase in viral clearance (PE)
    Espitia-Hernandez NRaVitamin Dstandard of careCOVID 19 outpatients, COVID-19 mild to moderateNA
    		28/7 uncontrolled
    • [uncontrolled] negative PCR on day 10: 100.0% (28/28)

    COVID-19 severe or critically meta-analysis

    COVID-VIT-D
          NCT04552951    		 RCTVitamin DcontrolCOVID-19 severe or criticallyhigh
    		274/269 inconclusive

      PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
      Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

       

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