Study explorer (study characteristics and results) method abbreviations pdf   xlsx

display ongoing studies
Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 hospitalized meta-analysis

Ranjbar
  IRCT20200204046369N1		 RCTmethylprednisolonedexamethasoneCOVID 19 hospitalizedsome concern
44/42 suggested
  • inconclusive 60 % decrease in deaths (PE) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 64 % decrease in mechanical ventilation with a moderate degree of certainty due to some concern in risk of bias
Metcovid
  NCT04343729		 RCTmethylprednisoloneplaceboCOVID 19 hospitalizedsome concern
209/207 inconclusive
  • inconclusive 8 % decrease in deaths,death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
Tang X
  NCT04273321		 RCTmethylprednisoloneplaceboCOVID 19 hospitalizedsome concern
43/43 suggested
  • inconclusive 0 % increase in clinical deterioration (PE) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 78 % increase in viral clearance ,viral clearance (time to event analysis only) with a moderate degree of certainty due to some concern in risk of bias

COVID-19 severe or critically meta-analysis

Edalatifard
  IRCT20200404046947N1		 RCTmethylprednisolonestandard of careCOVID-19 severe or criticallyhigh
34/34 suggested
  • suggested 71 % decrease in deaths,deaths (time to event analysis only) but with a low degree of certainty due to high risk of bias
  • suggested 11.0-fold increase in clinical improvement but with a low degree of certainty due to high risk of bias
Steroids-SARI
  NCT04244591		 RCTmethylprednisolonestandard of careCOVID-19 severe or criticallysome concern
24/23 inconclusive

    PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
    Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

     

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