metaEvidence - study list


	Study	study type RCT OBS RCT + OBS	Pathology	T1	T0	Patients	sample sizes	ROB	Results
locally advanced NSCLC - (neo)adjuvant (NA) locally advanced NSCLC - (neo)adjuvant (NA)
versus placebo plus SoC
	nivolumab plus SoC
	CheckMate 816, 2022 N Engl J Med 2022 Apr 11. NCT02998528	RCT	laNSCLC - NA - all population	nivolumab plus platinum doublet	placebo plus platinum doublet	patients with stage IB to IIIA resectable NSCLC, before surgery	179 / 179	NA	suggested	suggested 12.9-fold increase in pCR (PE) The results show that the Opdivo/chemotherapy treatment met the primary endpoint of pathologic complete response (pCR), with significantly more patients treated with the combination therapy showing no evidence of cancer cells in their resected tissue compared with the placebo arm