metaEvidence - study list


	Study	study type RCT OBS RCT + OBS	Pathology	T1	T0	Patients	sample sizes	ROB	Results
mNSCLC - L1 - PDL1 positive metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) mNSCLC - L1 - PDL1 positive
versus Standard of Care (SoC)
	pembrolizumab alone
	KEYNOTE-042 (PDL1>20%), 2019 Lancet 2019;393:1819-1830 Immunotherapy 2019; 11:1463-1478 Lung Cancer 2019; 135:188-195 NCT02220894	RCT	mNSCLC - L1 - PDL1 positive	pembrolizumab	platinium based chemotherapy	previously untreated, locally advanced or metastatic non-small-cell lung cancer with a PD-L1 TPS of 20% or greater	413 / 405	some concern	conclusif	demonstrated 23 % decrease in deaths (OS) (PE) suggested 25 % decrease in deaths (OS) (extension)
	KEYNOTE-042 (PDL1>1%), 2019 Lancet 2019;393:1819-1830 Immunotherapy 2019; 11:1463-1478 Lung Cancer 2019; 135:188-195 NCT02220894	RCT	mNSCLC - L1 - PDL1 positive	pembrolizumab	platinium based chemotherapy	previously untreated, locally advanced or metastatic non-small-cell lung cancer with a PD-L1 TPS of 1% or greater	637 / 637	some concern	conclusif	demonstrated 19 % decrease in deaths (OS) (PE) suggested 20 % decrease in deaths (OS) (extension)
	KEYNOTE-042 (PDL1>50%), 2019 Lancet 2019;393:1819-1830 Immunotherapy 2019; 11:1463-1478 Lung Cancer 2019; 135:188-195 Int J Cancer 2020 Nov 24. NCT02220894	RCT	mNSCLC - L1 - PDL1 positive	pembrolizumab	platinium based chemotherapy	previously untreated, locally advanced or metastatic non-small-cell lung cancer with a PD-L1 TPS of 50% or greater	299 / 300	some concern	conclusif	demonstrated 31 % decrease in deaths (OS) (PE) suggested 2 % decrease in deaths (OS) (extension) suggested 19 % decrease in progression or deaths (PFS)
	KEYNOTE-024 (PDL1>50%), 2016 N Engl J Med 2016;375:1823-1833 Lancet Oncol. 2017; 18:1600-1609 J. Clin. Oncol. 2019; 37:537-546 Lung Cancer 2019; 135:188-195 Cancer Sci 2020 Sep 14. J Clin Oncol 2021 Apr 19;JCO2100174. NCT02142738	RCT	mNSCLC - L1 - PDL1 positive	Pembrolizumab	ICC platinum-based chemotherapies regimens	patients who had previously untreated advanced stage IV NSCLC with PD-L1 expression on at least 50% of tumor cells	154 / 151	some concern	conclusif	demonstrated 40 % decrease in deaths (OS) (PE) demonstrated 50 % decrease in progression or deaths (PFS) (PE) suggested 38 % decrease in deaths (OS) (extension) suggested 50 % decrease in PFS (extension)
non squamous - mNSCLC - L1 - Wild Type (WT) metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) non squamous cell - mNSCLC - L1 non squamous - mNSCLC - L1 - Wild Type (WT)
versus pemetrexed plus platin
	pembrolizumab and pemetrexed plus platin
	KEYNOTE-021, 2016 Lancet Oncol 2016;17:1497-1508 J Thorac Oncol 2019 Jan;14(1):124-129. J Thorac Oncol 2019 Mar;14(3):553-559. J Thorac Oncol 2020 Sep 28;S1556-0864(20)30761-9. NCT02039674	RCT	non squamous - mNSCLC - L1 - Wild Type (WT)	pembrolizumab with carboplatin plus pemetrexed	carboplatin plus pemetrexed	patients with stage IIIB/IV, chemotherapy-naive, nonsquamous non-small-cell lung cancer	60 / 63	some concern	conclusif	demonstrated 47 % decrease in progression or deaths (PFS) (PE) suggested 46 % decrease in PFS (extension) demonstrated 2.1-fold increase in objective responses (ORR) (PE)
versus placebo plus SoC
	pembrolizumab plus SoC
	KEYNOTE-189, 2018 N Engl J Med 2018;378:2078-2092 Lancet Oncol. 2020; 21:387-397 J Med Econ 2018; 21:1191-1205 J Clin Oncol 2020; 38:1505-1517 Lung Cancer 2021 Feb 19;155:53-60. Ann Oncol 2021 Apr 21;S0923-7534(21)01146-7. NCT02578680	RCT	non squamous - mNSCLC - L1 - Wild Type (WT)	pembrolizumab plus pemetrexed plus platine	placebo plus pemetrexed plus platine	participants with advanced or metastatic nonsquamous non-small cell lung cancer who have not previously received systemic therapy for advanced disease	410 / 206	low	conclusif	demonstrated 51 % decrease in deaths (OS) (PE) demonstrated 48 % decrease in progression or deaths (PFS) (PE) suggested 44 % decrease in deaths (OS) (extension) suggested 52 % decrease in PFS (extension) more...
squamous - mNSCLC - L1 - all population metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) squamous cell - mNSCLC - L1 squamous - mNSCLC - L1 - all population
versus placebo plus SoC
	pembrolizumab plus SoC
	KEYNOTE-407, 2018 N Engl J Med 2018;379:2040-2051 J. Clin. Oncol. 2020; 38:271-280 NCT02775435	RCT	squamous - mNSCLC - L1 - all population	pembrolizumab plus platine and (nab)paclitaxel	placebo plus platine and (nab)paclitaxel	patients with confirmed stage IV squamous NSCLC who had received no previous systemic therapy for metastatic disease	278 / 281	low	conclusif	demonstrated 36 % decrease in deaths (OS) (PE) demonstrated 44 % decrease in progression or deaths (PFS) (PE)
mNSCLC - L2 - PDL1 positive metastatic/advanced NSCLC (mNSCLC) - 2nd line (L2) mNSCLC - L2 - PDL1 positive
versus docetaxel
	pembrolizumab (10mg/kg)
	KEYNOTE-010 (P:10 mg/kg ; PDL1>50%), 2016 Lancet 2016;387:1540-50 Ann. Oncol. 2019; 30:281-289 J Thorac Oncol 2019 May;14(5):793-801. NCT01905657	RCT	mNSCLC - L2 - PDL1 positive	pembrolizumab 10 mg/kg	docetaxel	patients with previously treated non-small-cell lung cancer with PD-L1 expression on at least 50% of tumour cells	151 / 152	high	conclusif	demonstrated 50 % decrease in deaths (OS) (PE) demonstrated 41 % decrease in progression or deaths (PFS) (PE) suggested 45 % decrease in deaths (OS) (extension) suggested 43 % decrease in PFS (extension)
	KEYNOTE-010 (P:10 mg/kg), 2016 Lancet 2016;387:1540-50 Ann. Oncol. 2019; 30:281-289 J Thorac Oncol 2019 May;14(5):793-801. NCT01905657	RCT	mNSCLC - L2 - PDL1 positive	pembrolizumab 10 mg/kg	docetaxel	patients with previously treated (one line or more) non-small-cell lung cancer with PD-L1 expression on at least 1% of tumour cells	346 / 343	high	conclusif	demonstrated 39 % decrease in deaths (OS) (PE) suggested 21 % decrease in progression or deaths (PFS) (PE)
	pembrolizumab (2mg/kg)
	KEYNOTE-010 (P: 2mg/kg ; PDL1>50%), 2016 Lancet 2016;387:1540-50 Ann. Oncol. 2019; 30:281-289 J Thorac Oncol 2019 May;14(5):793-801. NCT01905657	RCT	mNSCLC - L2 - PDL1 positive	pembrolizumab 2 mg/kg	docetaxel	patients with previously treated non-small-cell lung cancer with PD-L1 expression on at least 50% of tumour cells	139 / 152	high	conclusif	demonstrated 46 % decrease in deaths (OS) (PE) demonstrated 41 % decrease in progression or deaths (PFS) (PE)
	KEYNOTE-010 (P: 2mg/kg), 2016 Lancet 2016;387:1540-50 Ann. Oncol. 2019; 30:281-289 J Thorac Oncol 2019 May;14(5):793-801. NCT01905657	RCT	mNSCLC - L2 - PDL1 positive	pembrolizumab 2 mg/kg	docetaxel	patients with previously treated non-small-cell lung cancer with PD-L1 expression on at least 1% of tumour cells	344 / 343	high	conclusif	demonstrated 29 % decrease in deaths (OS) (PE) inconclusive 12 % decrease in progression or deaths (PFS) (PE)

mNSCLC - L1 - PDL1 positive metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) mNSCLC - L1 - PDL1 positive

non squamous - mNSCLC - L1 - Wild Type (WT) metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) non squamous cell - mNSCLC - L1 non squamous - mNSCLC - L1 - Wild Type (WT)

squamous - mNSCLC - L1 - all population metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) squamous cell - mNSCLC - L1 squamous - mNSCLC - L1 - all population

mNSCLC - L2 - PDL1 positive metastatic/advanced NSCLC (mNSCLC) - 2nd line (L2) mNSCLC - L2 - PDL1 positive