Study study type PathologyT1T0Patientssample sizesROB Results

mCRC - 1st line (L1) metastatic/advanced - colorectal cancer (mCRC) mCRC - 1st line (L1)

versus Bevacizumab plus FOLFOXIRI
atezolizumab plus FOLFOXIRI plus bevacizumab
AtezoTRIBE, 2022
  NCT03721653
RCTmCRC - 1st line (L1)atezolizumab plus FOLFOXIRI plus bevacizumabFOLFOXIRI plus bevacizumabPatients aged 18–75 years, with ECOG PS ≤2 if aged < 70 years, or ECOG PS 0 if aged 71–75 years145 / 73some concern
suggested
  • suggested 30 % decrease in progression or deaths (PFS) (PE)
1) The addition of atezolizumab to first-line FOLFOXIRI plus bevacizumab is safe and improved progression-free survival in patients with previously untreated metastatic colorectal cancer2) Pts with IS IC-high and/or TMB high pMMR mCRC seem to derive a survival benefit from adding atezo to FOLFOXIRI/bev as upfront treatment.