metaEvidence - study list


	Study	study type RCT OBS RCT + OBS	Pathology	T1	T0	Patients	sample sizes	ROB	Results	deaths (OS) E	progression or deaths (PFS) E	RFS/DFS E
mNSCLC - L1 - PDL1 positive metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) mNSCLC - L1 - PDL1 positive
versus Standard of Care (SoC)
	nivolumab alone
	CheckMate 026 (PDL1>5%), 2016 N Engl J Med 2017 Jun 22;376(25):2415-2426. NCT02041533	RCT	mNSCLC - L1 - PDL1 positive	Nivolumab	platinum-based chemotherapy	patients previously untreated had histologically confirmed squamous-cell or nonsquamous stage IV or recurrent NSCLC PD-L1 at >1%	211 / 212	some concern	inconclusive
	CheckMate 026 (PDL1>1%), 2016 N Engl J Med 2017 Jun 22;376(25):2415-2426. NCT02041533	RCT	mNSCLC - L1 - PDL1 positive	Nivolumab	platinium doublet chemotherapy	patients previously untreated had histologically confirmed squamous-cell or nonsquamous stage IV or recurrent NSCLC with PD-L1 >1%	271 / 270	some concern	inconclusive
mNSCLC - L2 - all population metastatic/advanced NSCLC (mNSCLC) - 2nd line (L2) mNSCLC - L2 - all population
versus docetaxel
	nivolumab alone
	CheckMate 078, 2019 J Thorac Oncol 2019; 14:867-875 Lung Cancer 2020 Nov 24;152:7-14. Lung Cancer 2021 Dec 27;165:71-81. NCT02613507	RCT	mNSCLC - L2 - all population	nivolumab	docetaxel	Patients with stage IIIB or IV or recurrent squamous or nonsquamous NSCLC progressing during or after one previous platinumbased doublet chemotherapy regimen. (predominantly Chinese patient)	338 / 166	some concern	conclusif
non squamous - mNSCLC - L2 - all population metastatic/advanced NSCLC (mNSCLC) - 2nd line (L2) non squamous cell - mNSCLC - L2 non squamous - mNSCLC - L2 - all population
versus docetaxel
	nivolumab alone
	CheckMate 057, 2015 N Engl J Med 2015;373:1627-39 Eur. J. Cancer 2018; 102:23-30 J. Clin. Oncol. 2017; 35:3924-3933 J Clin Oncol 2021 Mar 1;39(7):723-733. NCT01673867	RCT	non squamous - mNSCLC - L2 - all population	nivolumab	docetaxel	Patients with advanced (stage IIIb or IV or recurrent) nonsquamous NSCLC that had progressed during or after platinum-based chemotherapy	292 / 290	some concern	conclusif
squamous - mNSCLC - L2 - all population metastatic/advanced NSCLC (mNSCLC) - 2nd line (L2) squamous cell - mNSCLC - L2 squamous - mNSCLC - L2 - all population
versus docetaxel
	nivolumab alone
	CheckMate 017, 2015 J Thorac Oncol 2018; 13:194-204 J. Clin. Oncol. 2017; 35:3924-3933 N. Engl. J. Med. 2015; 373:123-35 J Clin Oncol 2021 Mar 1;39(7):723-733. NCT01642004	RCT	squamous - mNSCLC - L2 - all population	Nivolumab	Docetaxel	Patients with stage IIIB or IV squamous-cell NSCLC who had disease recurrence after only one prior platinum-containing regimen	135 / 137	some concern	conclusif

Study

study type

Pathology

Patients

sample sizes

ROB

Results

deaths (OS) E

progression or deaths (PFS) E

RFS/DFS E

NCT02041533

RCT

mNSCLC - L1 - PDL1 positive

Nivolumab

platinum-based chemotherapy

patients previously untreated had histologically confirmed squamous-cell or nonsquamous stage IV or recurrent NSCLC PD-L1 at >1%

211 / 212

NCT02041533

RCT

mNSCLC - L1 - PDL1 positive

Nivolumab

platinium doublet chemotherapy

patients previously untreated had histologically confirmed squamous-cell or nonsquamous stage IV or recurrent NSCLC with PD-L1 >1%

271 / 270

NCT02613507

RCT

mNSCLC - L2 - all population

nivolumab

docetaxel

Patients with stage IIIB or IV or recurrent squamous or nonsquamous NSCLC progressing during or after one previous platinumbased doublet chemotherapy regimen. (predominantly Chinese patient)

338 / 166

NCT01673867

RCT

non squamous - mNSCLC - L2 - all population

nivolumab

docetaxel

Patients with advanced (stage IIIb or IV or recurrent) nonsquamous NSCLC that had progressed during or after platinum-based chemotherapy

292 / 290

NCT01642004

RCT

squamous - mNSCLC - L2 - all population

Nivolumab

Docetaxel

Patients with stage IIIB or IV squamous-cell NSCLC who had disease recurrence after only one prior platinum-containing regimen

135 / 137

mNSCLC - L1 - PDL1 positive metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) mNSCLC - L1 - PDL1 positive

mNSCLC - L2 - all population metastatic/advanced NSCLC (mNSCLC) - 2nd line (L2) mNSCLC - L2 - all population

non squamous - mNSCLC - L2 - all population metastatic/advanced NSCLC (mNSCLC) - 2nd line (L2) non squamous cell - mNSCLC - L2 non squamous - mNSCLC - L2 - all population

squamous - mNSCLC - L2 - all population metastatic/advanced NSCLC (mNSCLC) - 2nd line (L2) squamous cell - mNSCLC - L2 squamous - mNSCLC - L2 - all population