metaEvidence - study list


	Study	study type RCT OBS RCT + OBS	Pathology	T1	T0	Patients	sample sizes	ROB	Results
mNSCLC - L2 - PDL1 positive metastatic/advanced NSCLC (mNSCLC) - 2nd line (L2) mNSCLC - L2 - PDL1 positive
versus docetaxel
	pembrolizumab (2mg/kg)
	KEYNOTE-010 (P: 2mg/kg ; PDL1>50%), 2016 Lancet 2016;387:1540-50 Ann. Oncol. 2019; 30:281-289 J Thorac Oncol 2019 May;14(5):793-801. NCT01905657	RCT	mNSCLC - L2 - PDL1 positive	pembrolizumab 2 mg/kg	docetaxel	patients with previously treated non-small-cell lung cancer with PD-L1 expression on at least 50% of tumour cells	139 / 152	high	conclusif	demonstrated 46 % decrease in deaths (OS) (PE) demonstrated 41 % decrease in progression or deaths (PFS) (PE)
	KEYNOTE-010 (P: 2mg/kg), 2016 Lancet 2016;387:1540-50 Ann. Oncol. 2019; 30:281-289 J Thorac Oncol 2019 May;14(5):793-801. NCT01905657	RCT	mNSCLC - L2 - PDL1 positive	pembrolizumab 2 mg/kg	docetaxel	patients with previously treated non-small-cell lung cancer with PD-L1 expression on at least 1% of tumour cells	344 / 343	high	conclusif	demonstrated 29 % decrease in deaths (OS) (PE) inconclusive 12 % decrease in progression or deaths (PFS) (PE)