metaEvidence - study list


	Study	study type RCT OBS RCT + OBS	Pathology	T1	T0	Patients	sample sizes	ROB	Results	deaths (OS) E	progression or deaths (PFS) E	RFS/DFS E
mNSCLC - L1 - all population metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) mNSCLC - L1 - all population
versus Standard of Care (SoC)
	cemiplimab
	EMPOWER lung1 (all population), 2021 Lancet 2021 Feb 13;397(10274):592-604. NCT03088540	RCT	mNSCLC - L1 - all population	cemiplimab	ICC	patients with confirmed stage IIIB or IIICor stage IV squamous or non-squamous non-small-celllung cancer	356 / 354	some concern	conclusif
mNSCLC - L1 - PDL1 positive metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) mNSCLC - L1 - PDL1 positive
versus Standard of Care (SoC)
	cemiplimab
	EMPOWER lung1 (PDL1>50%), 2021 Lancet 2021 Feb 13;397(10274):592-604. NCT03088540	RCT	mNSCLC - L1 - PDL1 positive	cemiplimab	ICC	patients with confirmed stage IIIB or IIICor stage IV squamous or non-squamous non-small-celllung cancer with PD-L1 expressed in at least 50% oftumour cells	283 / 280	some concern	suggested

Study

study type

Pathology

T1

T0

Patients

sample sizes

ROB

Results

deaths (OS) E

progression or deaths (PFS) E

RFS/DFS E

NCT03088540

RCT

mNSCLC - L1 - all population

cemiplimab

ICC

patients with confirmed stage IIIB or IIICor stage IV squamous or non-squamous non-small-celllung cancer

356 / 354

NCT03088540

RCT

mNSCLC - L1 - PDL1 positive

cemiplimab

ICC

patients with confirmed stage IIIB or IIICor stage IV squamous or non-squamous non-small-celllung cancer with PD-L1 expressed in at least 50% oftumour cells

283 / 280

mNSCLC - L1 - all population metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) mNSCLC - L1 - all population

versus Standard of Care (SoC)

cemiplimab

mNSCLC - L1 - PDL1 positive metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) mNSCLC - L1 - PDL1 positive

versus Standard of Care (SoC)

cemiplimab