metaEvidence - study list


	Study	study type RCT OBS RCT + OBS	Pathology	T1	T0	Patients	sample sizes	ROB	Results	deaths (OS) E	progression or deaths (PFS) E	RFS/DFS E
non squamous - mNSCLC - L1 - Wild Type (WT) metastatic/advanced NSCLC (mNSCLC) - 1st line (L1) non squamous cell - mNSCLC - L1 non squamous - mNSCLC - L1 - Wild Type (WT)
versus pemetrexed plus platin
	pembrolizumab and pemetrexed plus platin
	KEYNOTE-021, 2016 Lancet Oncol 2016;17:1497-1508 J Thorac Oncol 2019 Jan;14(1):124-129. J Thorac Oncol 2019 Mar;14(3):553-559. J Thorac Oncol 2020 Sep 28;S1556-0864(20)30761-9. NCT02039674	RCT	non squamous - mNSCLC - L1 - Wild Type (WT)	pembrolizumab with carboplatin plus pemetrexed	carboplatin plus pemetrexed	patients with stage IIIB/IV, chemotherapy-naive, nonsquamous non-small-cell lung cancer	60 / 63	some concern	conclusif
versus placebo plus SoC
	pembrolizumab plus SoC
	KEYNOTE-189, 2018 N Engl J Med 2018;378:2078-2092 Lancet Oncol. 2020; 21:387-397 J Med Econ 2018; 21:1191-1205 J Clin Oncol 2020; 38:1505-1517 Lung Cancer 2021 Feb 19;155:53-60. Ann Oncol 2021 Apr 21;S0923-7534(21)01146-7. NCT02578680	RCT	non squamous - mNSCLC - L1 - Wild Type (WT)	pembrolizumab plus pemetrexed plus platine	placebo plus pemetrexed plus platine	participants with advanced or metastatic nonsquamous non-small cell lung cancer who have not previously received systemic therapy for advanced disease	410 / 206	low	conclusif