• breast cancer - HR positive
• es-BC - HR positive - (neo)adjuvant (NA) 2
• es-BC - HR-positive - 1st line (L1) 1
• la/mBC - HR positive 2
• la/mBC - HR positive - (neo)adjuvant (NA) 3
• la/mBC - HR positive - NA - PIK3CA mutant
• la/mBC - HR-positive - 1st line (L1) 13
• la/mBC - HR positive - L1 - PIK3CA mutant 1
• la/mBC - HR-positive - 2nd line (L2) 20
• la/mBC - HR positive - L2 - all population 1
• la/mBC - HR positive - L2 - PIK3CA mutant 1

 

• phosphoinositide 3-kinase (PI3K) inhibitor
• buparlisib based treatment
• buparlisib plus fulvestrant

• versus all
• vs endocrine therapy
• vs fulvestrant

• study list
• mapping
• overview
• meta-analysis
• forest plot
• NMA
• excluded

Top evidence (RCT only, high risk of bias excluded) Best available evidence (possibly low or very low) All RCTs All studies (RCT+OBS)

Pathology:  la/mBC - HR positive - L2 - PIK3CA mutant;